不同剂量盐酸右美托咪定麻醉对宫颈癌腹腔镜手术患者血流动力学和认知功能的影响

Effects of different doses of dexmedetomidine hydrochloride anesthesia on hemodynamics and cognitive function in patients with cervical cancer laparoscopic surgery

目的 探究宫颈癌行腹腔镜手术患者经大、小剂量盐酸右美托咪定麻醉的效果。方法 选取62例宫颈癌行腹腔镜手术患者,以抽签法分为研究组(31例,小剂量盐酸右美托咪定)和对照组(31例,大剂量盐酸右美托咪定)。比较两组不同时点的血流动力学指标水平及认知功能评分。结果 与T_(0)比,T_(1)~T_(3)两组心率、平均动脉压均为降低后升高又降低的趋势,且研究组T时刻均高于对照组,中心静脉压均为升高后降低的趋势,且研究组T_(1)~T_(3)时刻均高于对照组;两组术后1 h~2 d认知功能评分均为逐渐升高的趋势,且研究组均高于对照组,差异有统计学意义(P<0.05)。结论 小剂量盐酸右美托咪定应用于宫颈癌行腹腔镜手术患者可降低对认知功能及血流动力学的影响,利于患者术后恢复。

Objective To explore the effect of high-dose and low-dose dexmedetomidine hydrochloride anesthesia in patients with cervical cancer undergoing laparoscopic surgery. Methods A total of 62 patients with cervical cancer undergoing laparoscopic surgery were selected and divided into the study group(31 cases, low-dose dexmedetomidine hydrochloride) and the control group(31 cases, high-dose dexmedetomidine hydrochloride) by the ballot method. The hemodynamic index levels and cognitive function scores were compared between the two groups at different time points. Results Compared with T, the heart rate and mean arterial pressure in the two groups from T_(1)~T_(3)in the trend of decreasing-increasing-decreasing, and the time of Tin the study group was higher than that in the control group, and the central venous pressure was in the trend of increasing-decreasing. The time from T_(1)~T_(3)in the study group was higher than that in the control group. The cognitive function scores of the two groups at 1 h~2 d after the operation all gradually increased, and the study group was higher than the control group, and the differences were statistically significant(P<0.05). Conclusion Low-dose dexmedetomidine hydrochloride in patients with cervical cancer undergoing laparoscopic surgery can reduce the impact on cognitive function and hemodynamics, which is conducive to the recovery of patients after surgery.