盐酸左氧氟沙星在盆腔炎患者中的应用效果及对炎性因子的影响研究

Application effect of levofloxacin hydrochloride in patients with pelvic inflammatory disease and its influence on inflammatory factors

目的 探讨盐酸左氧氟沙星在盆腔炎患者中的应用效果及对炎性因子的影响。方法 选取78例盆腔炎患者,以抽签法分为对照组(39例,氧氟沙星注射液治疗)和研究组(39例,盐酸左氧氟沙星注射液治疗),两组均治疗两周。将炎性因子治疗前后水平,不良反应治疗期间发生情况,临床治疗效果进行比较。结果 对照组的临床总有效率在治疗后低于研究组;与治疗前比,治疗后两组血清白细胞介素-8、C-反应蛋白、肿瘤坏死因子-α水平均降低,且研究组低于对照组,差异有统计学意义(P<0.05);两组治疗期间不良反应总发生率经比较,差异无统计学意义(P>0.05)。结论 盆腔炎患者应用盐酸左氧氟沙星治疗可抑制炎症反应,提升临床效果,且无较大不良反应,安全性较好。

Objective To investigate the application effect of levofloxacin hydrochloride in patients with pelvic inflammatory disease and its influence on inflammatory factors. Methods A total of 78 patients with pelvic inflammatory disease were selected and divided into the control group(39 cases, ofloxacin injection treatment) and the study group(39 cases, levofloxacin hydrochloride injection treatment) by ballot method, both groups were treated for 2 weeks. The levels of inflammatory factors before and after treatment, adverse reactions occurred during the treatment, the clinical treatment effect were compared. Results The total clinical effective rate of the control group was lower than that of the study group after treatment. Compared with before treatment, the serum levels of interleukin-8, C-reactive protein, and tumor necrosis factor-α in the two groups decreased after treatment, and the study group was lower than the control group, and the differences were statistically significant(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups during treatment(P>0.05). Conclusion The application of levofloxacin hydrochloride in patients with pelvic inflammatory disease can inhibit the inflammatory reaction and improve the clinical effect, and there is no major adverse reaction, and the safety is good.