干扰素外涂治疗女性尖锐湿疣与常规治疗的临床疗效分析

Analysis of clinical efficacy of interferon external application in the treatment of female condyloma acuminatum and conventional treatment

目的 评价外涂干扰素与常规治疗对女性尖锐湿疣的临床效果。方法 选取本院收治的60例尖锐湿疣患者,依据随机数字表法将其分为对照组与研究组,对照组使用二氧化碳激光疗法,研究组使用干扰素外涂,两组均治疗1个月并随访3个月。观察两组治疗前后白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、治疗后有效率、不良反应及随访期间的复发率。结果 治疗后两组血清IL-2水平均升高,研究组高于对照组;血清IL-4、IL-10水平均降低,研究组低于对照组;治疗后研究组总有效率(96.67%)高于对照组(80.00%),治疗后研究组不良反应总发生率、随访期间复发率(6.67%)、(3.33%)均低于对照组(30.00%)、(26.67%),差异有统计学意义(P<0.05)。结论 针对女性尖锐湿疣应用干扰素外涂治疗可以减轻机体炎症反应,降低复发率,有利于提升整体治疗效果。

Objective To evaluate the efficacy of interferon external application in the treatment of female condyloma acuminatum and conventional treatment. Methods A total of 60 patients with condyloma acuminatum admitted to our hospital were selected and divided into the study group and the control group according to the random number table method. The control group was treated with carbon dioxide laser therapy, and the study group was treated with interferon external. Both groups were treated for 1 month and followed up for 3 months. Interleukin-2(IL-2), interleukin-4(IL-4), interleukin-10(IL-10) before and after treatment,effective rate, adverse reaction after treatment, recurrence rate during follow-up in the two groups were observed. Results After treatment, the serum IL-2 levels in the two groups increased, the study group was higher than the control group, the serum IL-4 and IL-10 levels decreased, the study group was lower than the control group. After treatment, the effective rate of the study group(96.67%)was higher than that of the control group(80.00%), the total incidence after treatment and recurrence rate during follow-up(6.67%),(3.33%) were lower than those in the control group(30.00%),(26.67%), and the difference was statistically significant(P<0.05).Conclusion For female condyloma acuminatum, external application of interferon can reduce the body’s inflammatory response,reduce the recurrence rate, and help improve the overall treatment effect.