重组人干扰素α2b阴道泡腾片治疗宫颈HPV感染的效果观察

Observation on the effect of recombinant human interferon α2b vaginal effervescent tablets in the treatment of cervical HPV infection

目的 探讨在宫颈人乳头瘤病毒感染(HPV)的治疗中,予以患者重组人干扰素α2b阴道泡腾片的临床疗效。方法 本文以宫颈HPV感染患者为研究对象,以随机数字表法为分组依据,将样本(86例患者)分为两组,其中43例为对照组(接受克林霉素注射液治疗);另43例为试验组(接受重组人干扰素α2b阴道泡腾片联合克林霉素注射液治疗)。比较两组患者治疗前、治疗后各项指标。结果 治疗后,试验组总有效率明显高于对照组;与治疗前比,治疗后两组干扰素-γ、肿瘤坏死因子-α水平均升高,试验组高于对照组;治疗后两组白细胞介素-10、白细胞介素-4水平均降低,试验组低于对照组,差异具有统计学意义(P<0.05)。结论 宫颈HPV感染后,予以患者重组人干扰素α2b阴道泡腾片治疗,能够获得理想收益,能够减轻患者机体炎症反应。

Objective To explore the treatment of cervical human papillomavirus infection(HPV) with recombinant human interferon α 2b vaginal effervescent tablets. Methods In this paper, patients with cervical HPV infection were selected as the research objects, and the samples(86 patients) were divided into two groups based on the random number table method, of which 43 patients were the control group(treated with clindamycin injection);43 cases were in the experimental group(receiving recombinant human interferon α2b vaginal effervescent tablets combined with clindamycin injection). The indicators of the two groups of patients were compared before and after treatment. Results After treatment, the effective rate of the experimental group was significantly higher than that of the control group. Compared with before treatment, the levels of interferon-γ and tumor necrosis factor-α in the two groups increased after treatment, and the experimental group was higher than the control group;after treatment,the levels of interleukin-10 and interleukin-4 in the two groups decreased, the experimental group was lower than the control group,the differences were statistically significant(P<0.05). Conclusion After cervical HPV infection, the treatment with recombinant human interferon α2b vaginal effervescent tablets can achieve ideal benefits and reduce the body’s inflammatory response.