人乳头瘤病毒分型检测与宫颈癌疫苗在宫颈癌防治中的应用

Human papillomavirus type detection and application of cervical cancer vaccine in cervical cancer prevention and treatment

目的 分析在宫颈癌防治中,应用人乳头瘤病毒分型检测与宫颈癌疫苗的临床价值。方法 选取行宫颈癌筛查的女性560例。以宫颈病变程度为分组依据,将研究对象分为6组,其中392例为健康组、83例为宫颈炎组、51例为CINⅠ组、22例为CINⅡ组、12例为CINⅢ组;以是否接种宫颈癌疫苗为分组依据,将研究对象分为2组,其中130例为接种组、430例为未接种组。将人乳头瘤病毒分型检测作为宫颈癌筛查依据,比较不同组别人乳头瘤病毒感染率。结果 健康组、宫颈炎组、CINⅠ组、CINⅡ组、CINⅢ组的人乳头瘤病毒感染率比较,差异有统计学意义(P<0.05)。接种组的人乳头瘤病毒感染率低于未接种组,差异有统计学意义(P<0.05)。结论 宫颈病变程度不同、是否接种宫颈癌疫苗是影响宫颈癌筛查女性人乳头瘤病毒感染率的主要因素。

Objective To analyze the clinical value of human papillomavirus typing and cervical cancer vaccine in the prevention and treatment of cervical cancer. Methods A total of 560 women who underwent cervical cancer screening were selected. Based on the degree of cervical lesions, the study subjects were divided into 6 groups, including 392 cases in the healthy group, 83 cases in the cervicitis group, 51 cases in the CIN Ⅰ group, 22 cases in the CIN Ⅱ group, and 12 cases in the CIN Ⅲgroup;the cancer vaccine was used as the basis for grouping, and the subjects were divided into 2 groups, of which 130 were in the vaccinated group and 430 in the unvaccinated group. The human papillomavirus typing test was used as the basis for cervical cancer screening, and the infection rate of human papillomavirus in different groups was compared. Results Comparison of the infection rate of human papillomavirus among the healthy group, cervicitis group, CINⅠ group, CINⅡ group and CIN Ⅲ group, the difference was statistically significant(P<0.05). The infection rate of human papillomavirus in the vaccinated group was lower than that in the unvaccinated group, and the difference was statistically significant(P<0.05). Conclusion Different degrees of cervical lesions and whether or not to receive cervical cancer vaccine are the main factors affecting the infection rate of human papillomavirus in women undergoing cervical cancer screening.