抗阻运动对老年人炎症水平影响的Meta分析

Meta-analysis of the effect of resistance training on inflammation in elderly people

目的 探究抗阻运动对老年人群炎症水平的影响,为老年抗阻运动处方的制订提供一定依据。方法 计算机检索中、英文数据库关于抗阻运动对老年人炎症影响的随机对照研究,对文献进行筛选和数据提取,使用RevMan 5.3软件进行Meta分析。结果 共纳入11篇文献,404例观察对象。Meta分析示抗阻运动可以降低老年人的炎症水平,包括降低CRP(SMD=-0.68, 95%CI:-0.89~-0.46,P<0.001)、TNF-α(SMD=-0.73, 95%CI:-1.01~-0.45,P<0.001)和IL-6(SMD=-0.56, 95%CI:-1.05~-0.07,P=0.02)水平。亚组分析表明,当抗阻训练动作数≥8个时更有利于降低CRP水平(P<0.05);高强度抗阻运动降低老年人TNF-α水平的效果更好(P=0.0008);运动周期不超过12周、每周运动频率>2次、锻炼的动作数≥8个时,抗阻运动降低老年人IL-6水平的效果更好(P<0.05)。结论 抗阻运动对改善老年人群的慢性炎症状态有较好的效果。

Objective To investigate the effect of resistance training on inflammation in the elderly and to provide some basis for the formulation of exercise prescription. Methods Randomized controlled trials on the effects of resistance training on inflammation factors in the elderly people were retrieved from the databases.The retrieved literatures were screened and the data were extracted, and Meta-analysis was performed using RevMan 5.3 software. Results A total of 11 literatures were enrolled, including 404 subjects.The results showed that resistance training reduced the levels of inflammation factors in the elderly people, including C-reactive protein(CRP), tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6). Subgroup analysis showed that the level of CRP was decreased more significantly when the number of exercise was over 8. The effect of high intensity resistance training on TNF-α was better in elderly people. Resistance training was more effective in reducing IL-6 when the duration was less than 12 weeks, the number of exercise was over 8, and the frequency was more than 2 times per week. Conclusions Resistance training has a good effect on alleviating chronic inflammation in the elderly.