基于数据挖掘探讨黄衍寿教授治疗缓慢性心律失常的用药规律

Medication Rule of Professor Huang Yanshou for Treating Bradyarrhythmia Based on Data Mining

目的 探讨黄衍寿教授治疗缓慢性心律失常的用药规律。方法 收集黄衍寿教授门诊及住院部治疗缓慢性心律失常病例的中药处方,应用中医传承辅助平台系统,对黄衍寿教授治疗缓慢性心律失常的用药规律进行数据挖掘。结果 共纳入病例175例,中药处方175首,涉及药物共计140味。处方中使用频次超过30次的药物共18味,前10位依次为炙甘草、川芎、党参、赤芍、黄芪、红花、丹参、当归、桃仁、桂枝;支持度为45,置信度为0.8,得到药物组合及关联规则各30个,其中红花、赤芍、川芎,党参、黄芪,炙甘草、桂枝等为常用药物组合;相关度为8、惩罚度为3,挖掘出“桃仁、赤芍、当归、降香、川芎、红花”等新处方5首。结论 黄衍寿教授治疗缓慢性心律失常用药以益气、温阳、活血为主,佐以化痰。

Objective To discuss the medication rule of Professor Huang Yanshou for treating bradyarrhythmia.Methods The prescriptions of Chinese medicine used for bradyarrhythmia by Professor Huang Yanshou in outpatient service and inpatient department were collected.The medication rule of Professor Huang Yanshou was analyzed by the data-mining based on the platform system of traditional Chinese medicine inheritance support.Results A total of 175 cases were included, including 175 prescriptions of traditional Chinese medicine and 140 herbs.Totally 18 herbs were used frequently more than 30 times in the prescriptions and the top 10 herbs were liquoric root, Ligusticum wallichii, Codonopsis pilosula, red peony, Astragalus membranaceus, safflower, Salvia miltiorrhiza, Angelica sinensis, peach kernel, and Cinnamon Twig.With the 45 of support and 0.8 of confidence, there were 30 drug combinations and 30 association rules.Safflower-Red Peony-Ligusticum wallichii, Codonopsis pilosula-Astragalus membranaceus, and prepared liquoric root-Cinnamon Twig were the popular drug combinations.The relevancy was 8 and the punishment degree was 3.Peach Kernel, Red Peony, Angelica Sinensis, Lignum Dalbergiae, Ligusticum Wallichii, Safflower, and other five new prescriptions were excavated.Conclusion The herbs used by Professor Huang Yanshou for treatment of bradyarrhythmia were mainly benefiting qi, warming yang, promoting blood circulation, assisting with resolving phlegm.