探究未足月胎膜早破与阴道菌群微生态的关系

To explore the relationship between preterm premature rupture of membranes and vaginal flora

目的分析未足月胎膜早破(PPROM)与阴道菌群微生态的关系。方法选取70例PPROM患者纳入研究组,另选同期70例体检结果正常孕妇纳入对照组。对两组孕妇进行阴道微生态检查。评估两组患者阴道菌群微生态状况、阴道主要优势菌、阴道菌群密集度、阴道菌群多样性。结果研究组阴道微生态环境正常率8.6%较对照组85.7%低,革兰阳性球菌检出率30.0%较对照组11.4%高;研究组患者阴道菌群密集度、多样性均优于对照组,差异具有统计学意义(P<0.05)。结论阴道菌群微生态改变史是导致PPROM发病的重要诱因之一。

Objective To analysis of the relationship between preterm premature rupture of membranes(PPROM)and vaginal flora microecology.Methods 70 cases of PPROM patients were selected into the study group,and 70 pregnant women with normal physical examination results during the same period were selected into the control group.The vaginal microecological examination was performed.The microecological status of vaginal flora,the dominant vaginal bacteria,the density of vaginal flora,and the diversity of vaginal flora were evaluated in the two groups of patients.Results The normal rate of vaginal microecological environment in the study group 8.6%was lower than that in the control group(85.7%),and the detection rate of Gram-positive cocci 30.0%was higher than that in the control group(11.4%).The density and diversity of vaginal flora in the study group were better than those in the control group,the difference was statistically significant(P<0.05).Conclusion The history of microecological changes of vaginal flora is one of the important causes of PPROM.