妊娠不同时期甲亢患者检测甲状腺功能的临床价值

Diagnostic value of thyroid function in patients with hyperthyroidism at different stages of pregnancy

目的 探究妊娠不同时期甲状腺功能亢进症(甲亢)患者检测甲状腺功能的临床价值。方法 选取40例妊娠期甲亢患者为研究组,另选取同期40例妊娠非甲亢孕妇为对照组。两组受检者均进行甲状腺功能检测,比较两组血清甲状腺功能水平变化情况。结果 研究组孕中期血清三碘甲状腺原氨酸(T_(3))、甲状腺素(T_(4))水平分别为(5.81±0.12)、(305.74±38.42)nmol/L,明显高于对照组的(3.12±0.18)、(211.68±28.21)nmol/L,差异有统计学意义(P<0.05),促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))水平比较,差异无统计学意义(P>0.05)。研究组孕晚期T_(3)、T_(4)、FT_(4)水平明显高于对照组,TSH、FT_(3)水平低于对照组,差异有统计学意义(P<0.05)。结论 甲状腺功能检测在妊娠不同时期甲亢患者诊断中,为临床诊断甲亢疾病提供可靠数据,临床上可广泛应用。

Objective To explore the clinical value of thyroid function detection in patients with hyperthyroidism at different stages of pregnancy.Methods 40 patients with hyperthyroidism during pregnancy were selected as the study group,and 40 pregnant women without hyperthyroidism during the same period were selected as the control group.Thyroid function was detected in both groups,and the changes of serum thyroid function levels were compared between the two groups.Results The serum levels of triiodothyronine(T_(3)) and thyroxine(T_(4)) in the second trimester of the study group were(5.81±0.12) and(305.74±38.42) nmol/L,which were significantly higher than those in the control group(3.12±0.18) and(211.68±28.21)nmol/L,respectively.There was no significant difference in thyroid stimulating hormone(TSH),free triiodothyronine(FT_(3)) and free thyroxine(FT_(4)) levels(P>0.05).The levels of T_(3),T_(4) and FT_(4) in the study group were significantly higher than those in the control group,while the levels of TSH and FT_(3) were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Thyroid function detection method can be widely used in the diagnosis of hyperthyroidism in different stages of pregnancy to provide reliable data for clinical diagnosis of hyperthyroidism.