地屈孕酮联合低分子肝素钙治疗先兆流产患者的效果

Effect of dydrogesterone combined with low molecular weight heparin calcium in treatment of patients with threatened abortion

目的观察地屈孕酮联合低分子肝素钙对先兆流产患者的治疗效果。方法选取78例先兆流产患者作为研究对象,随机分为对照组与研究组,每组39例。对照组采用地屈孕酮单一治疗,研究组采用地屈孕酮联合低分子肝素钙治疗。观察两组患者妊娠结局和新生儿不良结局发生情况,并比较两组治疗满意度评分。结果研究组早产率、流产率低于对照组,正常足月妊娠率高于对照组,差异具有统计学意义(P<0.05)。研究组新生儿偏大、足月低体质量、喘息急促、新生儿畸形的发生率均低于对照组,差异具有统计学意义(P<0.05)。研究组治疗满意度评分为(89.32±9.10)分,高于对照组的(80.24±8.74)分,差异具有统计学意义(P<0.05)。结论地屈孕酮联合低分子肝素钙对先兆流产患者疗效显著,可改善妊娠结局,减少新生儿不良结局,提高患者满意度,值得在临床推广应用。

Objective To observe the effect of dydrogesterone combined with low molecular weight heparin calcium in treatment of patients with threatened abortion.Methods A total of 78 patients with threatened abortion from January 2020 to January 2021 in Department of Gynecology and Obstetrics in Zichuan District Hospital of Zibo City were selected as the research objects,and they were randomly divided into control group and study group,with 39 cases in each group.The control group was treated with dydrogesterone,and the study group was treated with dydrogesterone and low molecular weight heparin calcium.The pregnancy outcome of patients and neonatal adverse outcomes were observed in both groups,and the therapeutic satisfaction score was compared between the two groups.Results The premature birth rate and abortion rate in the study group were significantly lower than those in the control group,and the normal full-term pregnancy rate was significantly higher than that in the control group(P<0.05).The incidence rates of large newborns,low body weight at full term,shortness of breath and neonatal malformations in the study group were significantly lower than those in the control group(P<0.05).The therapeutic satisfaction score of the study group was(89.32±9.10),which was significantly higher than(80.24±8.74)of the control group(P<0.05).Conclusion Dydrogesterone combined with low molecular weight heparin calcium is effective in the treatment of patients with threatened abortion,which can improve pregnancy outcomes,reduce neonatal adverse outcomes and increase patient's satisfaction degree,so it is worthy of clinical application and popularization.