霉菌性阴道炎患者外周血、阴道分泌物炎症指标检测的临床意义

Clinical Significance of Detection of Inflammatory Indexes in Peripheral Blood and Vaginal Secretions of Patients with Fungal Vaginitis

目的探究外周血、阴道分泌物炎症指标检测在霉菌性阴道炎诊断中的临床价值。方法选取69例霉菌性阴道炎患者作为研究组,另选取69例健康体检者作为对照组。两组均实施外周血、阴道分泌物炎症指标检测,并对检测结果进行比较。结果研究组患者外周血与分泌物CD3^(+)、CD4^(+)、CD8^(+)T淋巴细胞百分比,Th1细胞因子[白细胞介素-2(IL-2)、肿瘤环死因子α(TNF-α)、γ干扰素(IFN-γ)]均低于对照组,Th2细胞因子[白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)]各项指标高于对照组,差异有统计学意义(P<0.05)。结论外周血、阴道分泌物炎症指标检测可为霉菌性阴道炎诊断提供参考依据,提高临床医师结合诊断结果合理用药,确保患者及时得到有效治疗。

Objective To explore the clinical value of peripheral blood and vaginal secretion inflammatory index detection in the diagnosis of fungal vaginitis.Methods 69 cases of fungal vaginitis patients were selected as the study group,and 69 healthy subjects were selected as the control group.The peripheral blood and vaginal secretions were tested for inflammatory indicators in both groups,and the test results were compared.Results The percentages of CD3^(+),CD4^(+),CD8^(+)T lymphocytes in peripheral blood and secretions of patients,Th1 cytokines[interleukin(IL)-2,tumor ring death factor alpha(TNF-α),interferon gamma(IFN-γ)]in the study group were lower than the control group,Th2 cytokines[Interleukin-4(IL-4),Interleukin-6(IL-6),Interleukin-10(IL-10)]were higher than the control group,the difference was statistically significant(P<0.05).Conclusion The detection of inflammatory indicators in peripheral blood and vaginal secretions can provide a reference for the diagnosis of fungal vaginitis,improve the rational use of drugs by clinicians based on the diagnosis results,and ensure that patients receive timely and effective treatment.