肥胖型多囊卵巢综合征患者临床及内分泌代谢特征分析

Clinical Characteristics and Endocrine and Metabolic Characteristics of Obese Polycystic Ovary Syndrome

目的分析肥胖型多囊卵巢综合征(PCOS)的临床特征及内分泌代谢特征。方法选取108例PCOS患者,根据体型差异分为肥胖型49例[体质量指数(BMI)≥25 kg/m2]设定为A组,非肥胖型59例(BMI<25 kg/m^(2))设定为B组。分析肥胖型PCOS患者的疾病特征。结果A组患者月经初潮年龄更大、孕次与流产次数更多,月经紊乱与月经稀发占比更高,黑棘皮病及高雄激素症占比更高,与B组比较,差异有统计学意义(P<0.05)。除身高外,A组患者各项人体测量数据均大于B组,差异有统计学意义(P<0.05)。A组患者各项激素水平均大于B组,差异有统计学意义(P<0.05)。除低密度脂蛋白胆固醇(LDL-C)与高密度脂蛋白胆固醇(HDL-C)外,A组患者总胆固醇(TC)(6.87±1.09)mmol/L、甘油三酯(TG)(2.48±0.36)mmol/L水平高于B组(6.12±1.03)mmol/L、(2.01±0.34)mmol/L,差异有统计学意义(P<0.05)。结论肥胖型PCOS患者临床特征较典型,其内分泌代谢功能有所下降,表现为激素水平及血脂水平升高,需要通过个体化治疗控制代谢紊乱程度,减少PCOS相关并发症,进而降低疾病风险性。

Objective To analyze the clinical and endocrine and metabolic characteristics of obese polycystic ovary syndrome(PCOS).Methods 108 PCOS patients were selected and divided into obese group(n=49)with body mass index(BMI)≥25 kg/m^(2)(group A)and non-obese group(n=59)with BMI<25 kg/m2(group B)according to body size difference.To analyze the disease characteristics of obese PCOS patients.Result The age of menarche in group A was older,the number of pregnancies and abortions were more frequent,the proportion of menstrual disorders and menstruation was higher,and the proportion of acanthosis nigricans and hyperandrogenism was higher than that in group B,and the differences were statistically significant(P<0.05).Except for height,all the anthropometric data of group A were higher than those of group B,and the differences were statistically significant(P<0.05).The hormone levels in group A were higher than those in group B,and the differences were statistically significant(P<0.05).In addition to low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C),the levels of TC(6.87±1.09)mmol/L and TG(2.48±0.36)mmol/L in group A were higher than those in group B(6.12±1.03)mmol/L and(2.01±0.34)mmol/L,and the differences were statistically significant(P<0.05).Conclusion The clinical characteristics of obese PCOS patients are typical,and their endocrine and metabolic functions are decreased,which is manifested by the increase of hormone levels and lipid levels.Individualized treatment is needed to control the degree of metabolic disorders,reduce the complications related to PCOS,and then reduce the risk of disease.