甲状腺癌术后复发/转移患者血清VEGF、ES的表达水平

A Study of Serum Levels of VEGF and ES in Thyroid Cancer Postoperative Recurrence and/or Metastasis

目的探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)、内皮抑素(endostatin,ES)在甲状腺癌术后转移患者中的价值。方法选取甲状腺癌术后患者112例,其中,甲状腺癌术后未复发组40例,局部复发组40例,肺转移组32例。健康对照组43例。采用酶联免疫分析法检测血清VEGF、ES水平,采用化学发光免疫分析法检测血清Tg水平。结果甲状腺癌肺转移组VEGF、ES均明显高于局部复发组,差异均有统计学意义(P<0.05)。局部复发组水平明显高于未复发组,两组相比较,差异有统计学意义(P<0.05),未复发组水平与对照组相比较,差异无统计学意义(P>0.05)。甲状腺乳头状癌患者与甲状腺滤泡状癌患者血清VEGF、ES水平比较,差异无统计学意义(P>0.05)。甲状腺癌术后复发患者血清甲状腺球蛋白水平与血清VEGF水平成直线正相关(P<0.001)。结论血清VEGF、ES水平在甲状腺癌术后转移/复发患者血清中高表达,可做为监测甲状腺癌术后复发/转移的辅助指标。

Objective To explore the significance of measuring vascular endothelial growth factor(VEGF)and endostatin(ES)levels in patients with thyroid cancer postoperative metastasis.Methods Levels of VEGF and ES in 112 patients with thyroid cancer were quantified.Serum levels of VEGF and ES were measured by enzyme-linked immunosorbent assay.Serum Tg level was determined by chemiluminescence immunoassay.For the study,40 cases without recurrence and/or metastasis,40 patients with locoregional recurrence,32 cases pulmonary metastasis,and 43 normal subjects(controls)were selected.Results VEGF and ES levels in the serum of patients with pulmonary metastasis were significantly higher than that in patients with locoregional recurrence,without recurrence and/or metastasis(P<0.05).There was no significant difference of VEGF and ES levels between patients without recurrence and/or metastasis and normal subjects(P>0.05).There was no significant difference of VEGF and ES levels between patients with papillary thyroid carcinoma and thyroid follicular carcinoma(P>0.05).We observed a linear correlation between serum VEGF and thyroglobulin levels in patients with recurrence and/or metastasis(P<0.001).Conclusion Levels of VEGF and ES are significantly elevated in patients with recurrence and/or metastasis,suggesting that these markers can be used as important indicators to predict recurrence and/or metastasis of thyroid cancer.