GE氟多功能模块自动化合成^(18)F-FDG教学实践

The Education on the Automatic Synthesis of ^(18)F-FDG Using GE Fluorine Multifunctional Module

正电子示踪剂是正电子发射断层扫描技术(positron emission tomography,PET)中核心要素之一,其开发与临床转化对PET成像技术的发展有至关重要的作用。目前国内从事正电子示踪剂研发制备的专业人才仍有很大缺口,加强该专业人才的培养是当前一个重要课题。本文以GE Tracerlab FX2N氟多功能合成设备为教学工具,拟从临床最常用的氟-18-2-氟代脱氧葡萄糖(2-[^(18)F]fluoro-2-deoxy-D-glucose,^(18)F-FDG)自动合成教学入手,采用理论与实践相结合的教学方式及“半开卷式”考核手段,引导学员了解正电子示踪剂合成的基本原理和相关技术工艺,认识氟多功能合成设备的模块功能、管线组装、阀门分布,提振学员对新型正电子示踪剂研发的兴趣与信心,旨在为今后武汉大学分子影像学科的发展及专业人才的培养积累经验。

Positron tracers are one of the key factors for positron emission tomography(PET).The development and clinical translation of positron tracers plays an important role in the development of PET imaging technology.However,in China,the lack of professionals engaging in the research and preparation of positron tracers made the training of professionals be a significant barrier.Herein,we used GE Tracerlab FX2N as a tool to teach the automatic synthesis of 2-[^(18)F]fluoro-2-deoxy-D-glucose(^(18)F-FDG),which was mostly used in clinical diagnosis.This teaching practice combined theory with practice and employed half-open-book examination to guide students to learn the basic principles and technology of positron tracer synthesis and to understand the synthesis equipment,including the module functions,pipeline assemble,and valve distribution.This practice was aimed at initiating students’interest and confidence in the research of novel positron tracers,and gathering experiences in cultivating professionals and developing the molecule imaging discipline of Wuhan University.