儿童单纯性肥胖程度与BNP、IGF-1和25-(OH)D3表达水平的相关性

Study on the correlation between the degree of simple obesity and expression levels of BNP,IGF-1 and 25-(OH)D3 in children

目的:探讨儿童单纯性肥胖程度与脑钠肽(BNP)、胰岛素样生长因子1(IGF-1)、25-羟基维生素D3[25-(OH)D3]表达水平的相关性。方法:选取儿科随访的单纯性肥胖患儿100例,分为轻中度肥胖组50例和重度肥胖组50例,同期选取健康体检的正常体质量儿童50名作为对照组。采用放射免疫分析法和酶联免疫吸附法检测3组血清BNP、IGF-1和25-(OH)D3水平,分析其对单纯性肥胖的诊断价值,并进行相关性分析。结果:重度肥胖组和轻中度肥胖组血清BNP水平差异无统计学意义(P>0.05),但均高于对照组(P<0.01);肥胖组IGF-1水平高于对照组(P<0.01),且随着肥胖程度的增加而上升(P<0.01);肥胖组25-(OH)D3水平低于对照组(P<0.01),且随着肥胖程度的增加而降低(P<0.05)。血清BNP、IGF-1、25-(OH)D3诊断单纯型肥胖的ROC曲线下面积分别为0.685、0.816、0.872。血清BNP、IGF-1和25-(OH)D3对单纯型肥胖的敏感度为55.24%、62.56%、78.36%,特异度为67.21%、78.28%、82.38%。相关分析显示,血清25-(OH)D3水平与儿童单纯型肥胖程度呈负相关关系(r=-0.614,P<0.05),血清IGF-1、BNP水平与单纯型肥胖程度均呈正相关关系(r=0.427、0.244,P<0.05)。结论:血清BNP、IGF-1、25-(OH)D3水平与单纯型肥胖程度密切相关。

Objective:To explore the correlation between the simple obesity and levels of brain natriuretic peptide(BNP),insulin-like growth factor 1(IGF-1)and 25-hydroxy vitamin D3[25-(OH)D3]in children.Methods:One hundred children with simple obesity followed up in department of pediatrics were divided into the mild and moderate obesity group(50 cases)and severe obesity group(50 cases).Meanwhile,50 healthy children with normal weight of physical examination were set as the control group.The serum levels of BNP,IGF-1 and 25-(OH)D3 in three groups were determined using radioimmunoassay and ELISA,the diagnostic value of which in simple obesity was identified,and their correlation were analyzed.Results:The difference of the serum level of BNP between the mild and moderate obesity group and severe obesity group was not statistically significant(P>0.05),and the serum levels of BNP in mild and moderate obesity group and severe obesity group were higher than that in control group(P<0.01).The serum levels of IGF-1 in obesity group were higher than that in control group(P<0.01),and which increased with the increasing of the degree of obesity(P<0.01).The serum levels of 25-(OH)D3 in obesity group were lower than that in control group(P<0.01),and which decreased with the increasing of the degree of obesity(P<0.05).The area under the diagnostic curve of serum 25-(OH)D3,IGF-1 and BNP was 0.872,0.816 and 0.685,respectively.The sensitivities of serum BNP,IGF-1 and 25-(OH)D3 to simple obesity were 55.24%,62.56%,78.36%,respectively,and the specificities of serum BNP,IGF-1 and 25-(OH)D3 to simple obesity were 67.21%,78.28%,82.38%,respectively.The results of correlation analysis showed that the serum level of 25-(OH)D3 was negatively correlated with the degree of simple obesity(r=-0.614,P<0.05),and the serum levels of IGF-1 and BNP were positively correlated with simple obesity in children(r=0.427,0.244,P<0.05).Conclusions:The serum levels of BNP,IGF-1 and 25-(OH)D3 are closely correlated with the degree of simple obesity.