急性脑桥梗死与基底动脉特征参数的相关性

Correlation between acute pons infarction and characteristic parameters of basilar artery

目的采用多模态磁共振技术探讨急性脑桥梗死患者基底动脉迂曲及斑块特征。方法搜集35例急性脑桥梗死和40例非急性脑桥梗死患者的临床、实验室及影像资料,所有患者均行多模态磁共振扫描,测量基底动脉迂曲角度及斑块特征(狭窄处管周、管腔及壁面积、参考处管周及管腔面积、斑块负荷、重构模式及重构率),采用单因素分析和多因素二元Logistic回归分析急性脑桥梗死的危险因素。结果单因素分析显示斑块负荷、重构模式及重构率组间的差异有统计学意义(P<0.05),基底动脉迂曲度、狭窄处管周、管腔、壁面积、参考处管周及管腔面积的差异无统计学意义(P>0.05)。多因素二元Logistic回归分析显示,斑块负荷为急性脑桥梗死的独立保护因素(OR=0.001,95%CI=0.000~0.306),重构模式为急性脑桥梗死的独立危险因素(OR=2.514,95%CI=1.380~4.580)。结论斑块负荷及重构模式可以影响急性脑桥梗死的发生。随着基底动脉斑块负荷的下降,急性脑桥梗死的发病率减低。基底动脉发生正性重构容易导致急性脑桥梗死的发生。

Objective To investigate basilar artery tortuosis and plaque characteristics in patients with acute pontine infarction by multimodal magnetic resonance technology.Methods Clinical,laboratory and imaging data of 35 patients with acute pontine infarction and 40 patients with non-acute pontine infarction were collected.The multimodal magnetic resonance scanning was performed to measure the angle of basilar artery tortuation and plaque characteristics(peritubular peritubular area at stenosis,lumen and wall area,reference peritubular and luminal area,plaque load,remodeling mode and remodeling rate).The univariate analysis and multivariate binary logistic regression were used to analyze the risk factors of acute pontine infarction.Results Univariate analysis showed that there were statistically significant differences in plaque load,remodeling mode and remodeling rate between groups(P<0.05),but no significant differences in basilar artery detour,peritubular periduct at stenosis,lumen,wall area,reference peritubular and luminal area(P>0.05).Multivariate binary logistic regression analysis showed that plaque load was an independent protective factor for acute pontine infarction(OR=0.001,95%CI=0.000-0.306)and the remodeling mode was an independent risk factor for acute pontine infarction(OR=2.514,95%CI=1.380-4.580).Conclusion Plaque load and remodeling patterns can affect the occurrence of acute pontine infarction.With a decrease in basilar plaque load,the incidence of acute pontine infarction decreases.Positive remodeling of the basilar artery can easily lead to acute pontine infarction.