益生菌辅助治疗新生儿感染性腹泻的临床研究

Clinical Study on Probiotics as Adjunctive Therapy for Neonatal Infectious Diarrhea

目的:探讨益生菌辅助治疗新生儿感染性腹泻的临床效果及对肠道菌群、肠黏膜屏障功能的影响。方法:选取2020年6月至2021年12月我院收治的80例感染性腹泻新生儿作为研究对象,随机分为观察组和对照组,各40例。对照组常规治疗(以防治脱水、纠正水电解质酸碱失衡、补充营养、抗感染治疗为主),观察组在常规治疗基础上予以益生菌(双歧杆菌乳杆菌三联活菌片)治疗。比较2组治疗总有效率,治疗前后肠道主要菌落数及血清D-乳酸、二胺氧化酶(DAO)水平。结果:观察组治疗总有效率(95.00%)明显高于对照组(77.50%),P <0.05。治疗前,2组肠杆菌、乳杆菌、双歧杆菌菌落数比较差异无统计学意义,P>0.05。治疗后,2组肠杆菌菌落数均有所下降,乳杆菌、双歧杆菌菌落数均有所上升;组间比较,观察组肠杆菌菌落数少于对照组,而乳杆菌和双歧杆菌菌落数多于对照组,P <0.05。治疗前,2组患者血清D-乳酸、DAO水平比较差异无统计学意义,P>0.05;治疗后,2组患者血清D-乳酸、DAO水平均有所下降,其中观察组更低,P <0.05。结论:益生菌辅助治疗新生儿感染性腹泻可提高临床疗效,有效调节肠道菌群分布,促进肠黏膜屏障功能恢复,值得临床推广使用。

Objective To investigate the clinical effect of probiotics in the adjunctive therapy for neonatal infectious diarrhea and its influence on intestinal flora and intestinal mucosal barrier function.Methods The 80 neonates with infectious diarrhea admitted to authors’ hospital from June 2020 to December 2021 were selected as the research subjects,and randomly divided them into observation group and control group,40 cases in each group.The control group received routine treatment(mainly to prevent dehydration,correct water electrolyte acid-base imbalance,supplement nutrition,and anti-infection treatment),and the observation group received probiotics(Bifidobacterium triplet living bacteria tablets) based on the control group.The total effective rate,the number of main intestinal bacteria and the levels of serum Dlactic acid and diamine oxidase(DAO) before and after treatment were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(95.00% vs 77.50%,P<0.05).Before treatment,there was no significant difference between the two groups in the number of Enterobacteriaceae,Lactobacillus and Bifidobacterium colonies(P>0.05).After treatment,the number of Enterobacteriaceae colony in both groups decreased,while the number of Lactobacillus and Rifidob acterium colony increased;Between groups the number of Enterobacteriaceae in the observation group was lower than that in the control group(P<0.05),but the number of Lactobacillus and Bifidob acterium in the observation group was higher than that in the control group(P>0.05).Before treatment,there was no significant difference in serum D-lactic acid and DAO levels between the two groups(P>0.05);After treatment,the levels of serum D-lactic acid and DAO in the two groups decreased,and the levels in the observation group were significantly lower than those in the control group(P <0.05).Conclusion Probiotics as adjunctive therapy for neonatal infectious diarrhea can improve the clinical efficacy,effectively regulate the distribution of intestinal flora,and promote the recovery of intestinal mucosal barrier function,which is worthy of clinical popularization and application.