曲美他嗪联合沙库巴曲缬沙坦治疗慢性充血性心力衰竭的临床效果及对患者心功能的影响

Clinical Effect of Trimetazidine Combined with Sacubatrovalsartan in the Treatment of Chronic Congestive Heart Failure and the Impact on Patients' Cardiac Function

目的探讨曲美他嗪联合沙库巴曲缬沙坦治疗慢性充血性心力衰竭的临床效果及对患者心功能的影响。方法选取2018年10月至2020年10月我院收治的88例慢性充血性心力衰竭患者,随机分为对照组(n=44)和观察组(n=44)。对照组采用常规抗心衰方案治疗,观察组在对照组基础上采用曲美他嗪联合沙库巴曲缬沙坦治疗。比较两组的临床疗效及心功能指标。结果观察组治疗总有效率为95.45%,明显高于对照组的81.82%(P<0.05)。治疗后,两组的LVEF高于治疗前,NT-proBNP水平低于治疗前,6MWT距离长于治疗前(P<0.05);与对照组相比,观察组的LVEF较高,NT-proBNP水平较低,6MWT距离较长(P<0.05)。结论曲美他嗪联合沙库巴曲缬沙坦治疗慢性充血性心力衰竭的效果显著,可明显改善患者的心功能,值得临床推广应用。

Objective To explore the clinical effect of trimetazidine combined with sacubatrovalsartan in the treatment of chronic congestive heart failure and the impact on patients'cardiac function.Methods 88 cases of patients with chronic congestive heart failure admitted to our hospital from October 2018 to October 2020 were selected and randomly divided into control group(n=44)and observation group(n=44).The control group was given conventional anti heart failure regimen,and the observation group was treated with trimetazidine and sacubatrovalsartan on the basis of the control group.The clinical efficacy and cardiac function indicators were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.45%,significanly higher than 81.82%in the control group(P<0.05).After treatment,the LVEF of the two groups were higher than those before treatment,the NT-proBNP levels were lower than those before treatment,and the 6MWT distance were longer than those before treatment(P<0.05);Compared with the control group,the LVEF of the observation group was higher,the NT-proBNP level was lower,and the 6MWT distance was longer(P<0.05).Conclusions Trimetazidine combined with sacubatrovalsartan has significant effect in the treatment of chronic congestive heart failure,and can significantly improve the cardiac function of patients,which is worthy of clinical promotion and application.