阿司匹林联合硫酸镁治疗重度子痫前期的效果观察

Observation on the Effect of Aspirin Combined with Magnesium Sulfate in the Treatment of Severe Preeclampsia

目的观察阿司匹林联合硫酸镁治疗重度子痫前期的临床效果。方法选取2018年12月至2021年12月我院收治的72例重度子痫前期孕妇,随机分为两组各36例。对照组予以硫酸镁治疗,观察组予以阿司匹林联合硫酸镁治疗。比较两组的治疗效果、凝血指标及母婴结局。结果观察组治疗总有效率为94.44%,高于对照组的77.78%(P<0.05)。治疗后,两组的PT、APTT均延长,D-D水平均降低,且观察组PT、APTT长于对照组,D-D水平低于对照组(P<0.05)。观察组的早产、剖宫产、胎盘早剥、胎儿窘迫及新生儿窒息发生率均低于对照组(P<0.05)。结论阿司匹林联合硫酸镁治疗重度子痫前期的临床效果显著,可有效改善孕妇的凝血功能,减少不良母婴结局的发生,值得临床推广应用。

Objective To observe the clinical effect of aspirin combined with magnesium sulfate in the treatment of severe preeclampsia.Methods 72 pregnant women with severe preeclampsia admitted to our hospital from December 2018 to December 2021 were selected and randomly divided into two groups,with 36 cases in each group.The control group was treated with magnesium sulfate,and the observation group was treated with aspirin combined with magnesium sulfate.The treatment effect,coagulation indicators and maternal and infant outcomes were compared between the two groups.Results The total effective rate of the observation group was 94.44%,higher than 77.78%of the control group(P<0.05).After treatment,the PT and APTT of the two groups prolonged,and the D-D levels decreased(P<0.05);The PT and APTT of the observation group were longer than those of the control group,and the D-D level was lower than that of the control group(P<0.05).The incidences of premature birth,cesarean section,placental abruption,fetal distress and neonatal asphyxia in the observation group were lower than those in the control group(P<0.05).Conclusions Aspirin combined with magnesium sulfate has significant clinical effect in the treatment of severe preeclampsia,and can effectively improve the coagulation function of pregnant women,and reduce the adverse maternal and infant outcomes,which is worthy of clinical promotion and application.