不同中药调控Wnt/GSK-3β/β-连环素蛋白通路治疗骨质疏松症的研究现状

Research status of various traditional Chinese medicines in the treatment of osteoporosis through Wnt/GSK-3β/β-catenin pathway

Wnt/GSK-3β/β-连环素蛋白(β-catenin)通路是一种作用广泛的经典信号通路,在骨骼生长发育及骨髓干细胞转化等多种过程起重要作用。笔者就不同中药通过该通路对骨重建影响的文献研究,了解到苦味药独活、藜芦、姜黄、黄连、黄芩,补肾药龟板、淫羊藿、骨碎补,补气药黄芪等单味中药及左归丸、右归丸、金贵肾气丸等补肾中药复方通过调控Wnt/GSK-3β/β-catenin通路,抑制GSK-3β的表达,促使更多的β-catenin向核内转移,进而诱导骨髓干细胞向成骨细胞分化,抑制破骨,以达到增加骨密度、增强骨的机械应力、治疗骨质疏松的作用效果,通过观察中药对Wnt/GSK-3β/β-catenin通路各种蛋白表达的影响,阐明中药对骨代谢的调节作用,为开展中药复方治疗骨质疏松症的研究与开发提供思路。

Wnt/GSK-3β/β-catenin pathway is a widely acting classical signaling pathway that plays an important role in various processes such as bone growth and development and bone marrow stem cell transformation. In this paper, we studied the literature on the effects of different traditional Chinese medicines on bone remodeling through this pathway, and learned that single herbs such as bitter herbs Duhuo, Veratrum, Curcuma longa, Coptis chinensis, and Scutellaria baicalensis, tonifying kidney drugs Tortoise Plate, Herba Epimedii, Rhizoma Drynariae, invigorating qi drugs Astragalus membranaceus, and tonifying kidney Chinese medicine compounds such as Zuogui pills, Yougui pills, and Jingui Shenqi pills inhibited the expression of GSK-3β by regulating the Wnt/GSK-3β/β-catenin pathway, promoted more β-catenin to transfer into the nucleus, and then induced bone marrow stem cells to differentiate into osteoblasts and inhibited bone fragmentation, in order to achieve the effects of increasing bone mineral density. By observing the effect of traditional Chinese medicine on the expression of various proteins of Wnt/GSK-3β/β-catenin pathway, the regulatory effect of traditional Chinese medicine on bone metabolism was elucidated, providing ideas for the research and development of traditional Chinese medicine compound in the treatment of osteoporosis.