骨质疏松进程中破骨细胞能量代谢重编程研究进展

Research progress in energy metabolism reprogramming of osteoclasts in the process of osteoporosis

骨质疏松症是一种成骨细胞和破骨细胞之间失衡造成的代谢性骨病。破骨细胞通过吸收葡萄糖、脂肪酸、氨基酸等产生的能量,并分化激活代谢程序。代谢重编程产生能量以支持单核前体细胞向多核破骨细胞的表型改变,并促进骨吸收,这是终末分化成熟破骨细胞主要的功能,所有代谢途径紧密联系。因此研究不同能量、不同环境下,破骨细胞代谢重编程具有重要的意义。

Osteoporosis is a metabolic bone disease caused by an imbalance between osteoblasts and osteoclasts. Osteoclasts absorb energy produced by glucose, fatty acids, amino acids, etc, and differentiate to activate metabolic processes. The energy generated by metabolic reprogramming not only supports the phenotypic change of monocyte progenitor cells to polynuclear osteoclasts, but also promotes bone resorption, which is the main function of terminally differentiated mature osteoclasts, and all metabolic pathways are closely linked. Therefore, it is of great significance to study the metabolic reprogramming of osteoclasts under different energy and different environment.