原发性闭角型青光眼合并视网膜色素变性的临床特征分析

Analysis of clinical features of primary angle closure glaucoma with retinitis pigmentosa

目的分析原发性闭角型青光眼合并视网膜色素变性患者的临床特征。方法本研究纳入2013年4月至2017年4月于首都医科大学附属北京同仁医院眼科中心住院治疗的原发性闭角型青光眼(primary angle closure glaucoma,PACG)合并视网膜色素变性(retinitis pigmentosa,RP)患者32例,和同期入院的不合并RP的PACG患者229例。根据青光眼类型将其分为4组,急性闭角型青光眼合并RP组(acute angle closure glaucoma with retinitis pigmentosa,AACG-RP)12例、慢性闭角型青光眼合并RP组(chronic angle closure glaucoma with retinitis pigmentosa,CACG-RP)20例、急性闭角型青光眼不合并RP组(AACG-non RP)94例、慢性闭角型青光眼不合并RP组(CACG-non RP)135例,比较4组患者的发病年龄和眼轴长度等参数。结果患者平均发病年龄AACG-RP组(39.00±12.07)岁、CACG-RP组(43.85±12.79)岁、AACG-non RP组(66.44±9.40)岁、CACG-non RP组(63.95±10.42)岁,4组之间差异有统计学意义(F=47.70,P<0.05)。患者平均眼轴长度AACG-RP组(21.31±1.37)mm、CACG-RP组(22.33±1.09)mm、AACG-non RP组(22.31±1.03)mm、CACG-non RP组(22.47±1.01)mm,4组之间差异有统计学意义(F=19.09,P<0.05)。结论原发性闭角型青光眼患者合并视网膜色素变性患者中,急性闭角型青光眼患者较慢性闭角型青光眼患者发病更早,眼轴更短。原发性闭角型青光眼合并视网膜色素变性患者,尤其是急性闭角型青光眼合并视网膜色素变性患者较无视网膜色素变性者发病年龄更早,且眼轴更短。

Objective To investigate the clinical features of primary angle closure glaucoma(PACG)patients with retinitis pigmentosa(RP).Methods This study included 32 patients suffering from PACG combined with RP hospitalized in Beijing Tongren Hospital,Capital Medical University from April 2013 to April 2017,and 229 PACG patients without RP hospitalized in the same period.According to the type of glaucoma,patients were divided into 4 groups,12 patients in acute angle closure glaucoma with RP group(AACG-RP),20 patients in chronic angle closure glaucoma with RP group(CACG-RP),94 patients in AACG-non RP group and 135 patients in CACG-non RP group.The age of onset and axial length(AL)were compared among these four groups.Results Mean age of onset was(39.00±12.07)years in AACG-RP group,(43.85±12.79)years in CACG-RP group,(66.44±9.40)years in AACG-non RP group and(63.95±10.42)years in CACG-non RP group.The difference between the four groups was statistically significant(F=47.70,P<0.05).The mean AL was(21.31±1.37)mm in AACG-RP group,(22.33±1.09)mm in CACG-RP group,(22.31±1.03)mm in AACG-non RP group and(22.47±1.01)mm in CACG-non RP group.The difference between the four groups was statistically significant(F=19.09,P<0.05).Conclusions In PACG patients combined with RP,AACG patients had earlier age of onset and shorter AL than CACG patients.PACG patients combined with RP had earlier age of onset and shorter AL than those without RP,especially those with AACG combined with RP.