高效价血浆在重症腺病毒肺炎患儿中的应用效果

Effect of high Titer Plasma on Children with severe Adenovirus Pneumonia

目的 探究高效价血浆在重症腺病毒肺炎患儿中的应用效果。方法 回顾性分析2018年1月至2019年12月郑州大学附属儿童医院收治的92例重症腺病毒肺炎患儿,按照治疗方式将患儿分为非高效价血浆组和高效价血浆组,分别为51例、41例。非高效价血浆组接受常规治疗,高效价血浆组在常规治疗的基础上接受高效价血浆治疗。观察比较两组患儿的感染指标、血气指标及体温正常时间、有创呼吸机撤离时间、转出PICU时间、出院时间及存活率。结果 与非高效价血浆组相比,治疗前和治疗后高效价血浆组的各项感染指标、血气指标水平比较差异无统计学意义(P> 0.05);与治疗前相比,治疗后两组的白细胞水平均升高,中性粒细胞和C反应蛋白水平均降低,差异有统计学意义(P <0.05)。与治疗前相比,治疗后两组的各项血气指标水平均升高,差异有统计学意义(P <0.05)。与非高效价血浆组相比,高效价血浆组的有创呼吸机车里时间、转出PICU时间、出院时间差异无统计学意义(P> 0.05),高效价血浆组的体温正常时间缩短,存活率升高,差异有统计学意义(P <0.05)。结论 在重症腺病毒肺炎患儿的治疗中应用高效价血浆,能够有效缩短体温恢复时间,且不会影响感染指标、血气指标及恢复效率,还可提高存活率,临床值得应用。

Objective To investigate the effect of high titer plasma in children with severe adenovirus pneumonia.Methods Retrospective analysis was made on 92 children with severe adenovirus pneumonia admitted to the Affiliated Children's Hospital of Zhengzhou University from January 2018 to December 2019.According to the treatment methods,the children were divided into non-high potency plasma group and high potency plasma group,which were 51 cases and 41 cases respectively.The non-high potency plasma group received routine treatment,while the high potency plasma group received high potency plasma treatment on the basis of routine treatment.The infection index,blood gas index,normal temperature time,invasive ventilator evacuation time,PICU transfer time,discharge time and survival rate were observed and compared between the two groups.Results Compared with the non-high potency plasma group,there was no significant difference in the levels of infection indicators and blood gas indicators between the high potency plasma group before and after treatment(P>0.05);Compared with that before treatment,the level of white blood cells in the two groups increased,while the levels of neutrophils and C-reactive protein decreased after treatment,with a statistically significant difference(P<0.05).Compared with before treatment,the levels of blood gas indexes in the two groups after treatment were significantly higher(P<0.05).Compared with the non-high potency plasma group,there was no statistically significant difference in the invasive breathing time in the high potency plasma group,the time of transferring out of the PICU,and the time of leaving hospital(P>0.05).The normal temperature time in the high potency plasma group was shortened,and the survival rate was increased,with statistically significant differences(P<0.05).Conclusion The application of high titer plasma in the treatment of children with severe adenovirus pneumonia can effectively shorten the temperature recovery time,and will not affect the infection indicators,blood gas indicators and recovery efficiency,but also improve the survival rate,which is worthy of clinical application.