子宫动脉血流动力参数联合血栓弹力图用于复发性流产预测的临床价值

Clinical value of uterine artery hemodynamic parameters combined with thromboelastogram in predicting recurrent spontaneous abortion

目的 分析子宫动脉血流动力参数联合血栓弹力图在复发性流产中的预测价值。方法 回顾性分析2020年5月至2021年5月郑州市金水区总医院接受治疗的复发性流产患者的临床资料,基于特定时间段内选取40例,将其作为观察组;另选取同时期行孕前检查的正常妊娠妇女36例,将其作为对照组。上述研究对象均接受子宫动脉血流动力参数及血栓弹力图检查。对子宫动脉血流动力参数、血栓弹力图参数、凝血功能、妊娠丢失率进行重点比较。结果 观察组搏动指数(PI)、阻力指数(R1)、收缩期峰值流速/舒张末期流速(SD)水平均显著高于对照组,差异有统计学意义(P <0.05);观察组凝固时间(K值)、R值均显著低于对照组,差异有统计学意义(P <0.05),最大振幅(MA值)、凝固角(α值)均显著高于对照组,差异有统计学意义(P <0.05);观察组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)显著低于对照组,差异有统计学意义(P <0.05),纤维蛋白原(FIB)显著高于对照组,差异有统计学意义(P <0.05);观察组妊娠流失率为17.50%(7/40),显著高于对照组的2.78%(1/36),差异有统计学意义(P <0.05)。结论 与正常女性相比,复发性流产患者子宫动脉血流动力参数、血栓弹力图异常,可将该数据作为识别高危孕妇的参考数据,降低妊娠丢失率。

Objective To analyze the predictive value of uterine artery hemodynamic parameters combined with thromboelastography in recurrent abortion.Methods The clinical data of patients with recurrent abortion who were treated in the General Hospital of Jinshui District,Zhengzhou City,Henan Province were analyzed retrospectively.Based on the specific time period(May 2020 to May 2021),40 patients were selected as the observation group,and 36 normal pregnant women who were examined before pregnancy in the same period were selected as the control group,The hemodynamic parameters of uterine artery,parameters of thromboelastogram,coagulation function and pregnancy loss rate were compared.Results The levels of pulsation index(PI),resistance index(R1),peak systolic velocity/end diastolic velocity(SD)in the observation group were significantly higher than those in the control group(P<0.05);The coagulation time(K value)and R value in the observation group were significantly lower than those in the control group(P<0.05),the maximum amplitude(MA value)and coagulation angle(P<0.05);The prothrombin time(PT)and activated partial thromboplastin time(APTT)in the observation group were significantly lower than those in the control group(P<0.05),and fibrinogen(FIB)was significantly higher than those in the control group(P<0.05);The pregnancy loss rate in the observation group was 17.50%(7/40),which was significantly higher than that in the control group 2.78%(1/36)(P<0.05).Conclusion Compared with normal women,the uterine artery hemodynamic parameters and thromboelastogram of patients with recurrent abortion are abnormal,which can be used as reference data to identify high-risk pregnant women and reduce pregnancy loss rate.