工程益生菌用于疾病诊断治疗和细胞工厂的研究进展

Research progress of engineering probiotics in disease diagnosis,treatment and cell factory

随着科学技术的发展,益生菌因其独特的生理功能逐渐影响人们的日常生活,其用途已被大众熟知并且接受,而利用合成生物学对益生菌进行改造后得到的工程益生菌也已逐渐成为相关领域的研究热点。作为下一代活性治疗药物,经过改造后得到的工程益生菌可针对特定疾病发挥其独特作用,例如,在肠道菌群微环境、代谢性疾病的监测以及肿瘤靶向治疗等方面已广泛应用。此外,随着益生菌在食品工业中的出色作用和益生菌的功能,其微生物代谢特性也越来越受到人们的关注,工程益生菌在代谢过程中不仅能产生有机酸、胺类、维生素等多种产物,还能改善发酵食品口味,增加产品营养,在食品工业中广泛应用。重点介绍了对经过改造后的工程益生菌的作用及其应用前景。

With the development of science and technology,people's daily life was gradually affected by probiotics because of their unique physiological functions,and their uses have been well known and accepted by the public.The engineering probiotics obtained from the transformation of probiotics by synthetic biology had gradually become a hot topic in related fields.As the next generation of active therapeutic drugs,the modified engineering probiotics could play a unique role in specific diseases,such as intestinal flora microenvironment,metabolic disease monitoring and tumor targeted therapy.In addition,with the excellent role of probiotics in the food industry and the function of probiotics,its microbial metabolic characteristics were more concerned.Engineering probiotics could not only produce organic acids,amines,vitamins and other products in the metabolic process,but also improved the taste of fermented food and increased product nutrition,showing a wide range of applications in the food industry.The function and application prospects of the modified engineering probiotics were focused.