1MUNRO I C, FORD R A, KENNEPOHL E, et al. Correlation of structural class with no observed effect levels: a proposal for establishing a threshold of concern [ J ]. Food Chemical Toxicol, 1996, 34 : 829 -867.
2US FD&C Act. Federal food, drug and cosmetic Act, as amended Title 21 U. S. Code, U. S. Washington: Governmental Printing Office, 1958.
3RULIS. Establishing a threshold of concern [ M ]// BONIN J J , STEVENSON D E. Risk assessment in setting national priorities. NY : Plenum Press, 1989:271-278.
4GOLD L S, SAWYER C B, MAGAW R, et al. A carcinogenesis potency database of the standardized results of animal bioassays[ J ]. Environ Health Perspectives, 1984,58: 9-319.
5KROES R, GALLIC, MUNRO I, SCHILTER B, etal. Threshold of toxicological concern for chemical substances present in the diet: a practical tool for assessing the need for toxicity testing [ J ]. Food Chem Toxicol, 2000, 38:255-312.
6KROES R, RENWICK A G, CHEESEMAN M, et al. Structurebased thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet [ J]. Food Chem Toxicol,2004, 42 : 65-83.
7US FDA. Food additives: threshold of regulation of substances used in food contact articles: final rule [ J ]. Federal Register, 1995,60 : 36582-36596.
8SCF. Opinion of the Scientific Committee on Food on the scientific basis of the concept of threshold of regulation in relation to food contact materials. Reports of the Scientific Committee on Food, 39th Series, catalogue no: GT 07 97644-EN, Office for Official Publications of the European Community, L-2985 Luxembourg, 1996.
9SCF. Guidelines of the Scientific Committee on Food for the presentation of an application for a safety assessment of a substance to be used in food contact materials prior to its authorisation[ M]. 2001.
10JECFA, The safety evaluation of natural flavouring complexes. WHO Food Additives Series, No 52 [ M ]. 1996.
