乳酸链球菌素(Nisin)的生物合成研究进展

Research Progress on Biosynthesis of Nisin

文章对天然防腐剂——乳酸链球菌素(Nisin)的生物合成进展进行了综述。对乳酸链球菌素的化学结构以及特点、结构与功能的关系、生物合成基因簇、翻译后修饰、生物合成调控水平等在化学、生物学等机理方面进行了介绍,希望国内广大科研工作者由此而得到启发,在发现新的细菌素方面提供一些思路。

The progress in biosynthesis of Nisin,a natural preservative,is reviewed in this paper.The mechanisms in chemistry and biology,including the chemical structure and characteristics,the relationship between structure and function,biosynthetic gene cluster,post-translational modification,biosynthetic regulation level of Nisin and so on are introduced.It is hoped that the majority of domestic scientific researchers will be inspired by this and provide some ideas in discovering new bacteriocins.