基于经典胰岛素传导及炎症信号通路的相互作用中药改善胰岛素抵抗作用研究进展

Research Progress of Traditional Chinese Medicine on Alleviating Insulin Resistance Based on Classical Insulin Conduction and Inflammatory Signal Pathway

胰岛素抵抗(Insulin Resistance,IR)是2型糖尿病(Type 2 diabetes,T2DM)最主要的发病机制之一。治疗T2DM的关键就是改善机体IR的状态。中医药在改善IR方面有其得天独厚的优势,近年来越来越多的医学工作者开始关注中医药在T2DM改善IR方面的作用,对其分子机制方面的研究也越来越深入。鉴于IR与慢性低度炎症之间错综复杂的关系,本文基于经典胰岛素传导及炎症信号两大类通路,从中药活性成分、提取物以及中药复方三个方面综述了近十年中药在改善IR的相关研究,旨在为中药治疗T2DM、改善IR的研究与治疗提供借鉴并为进一步的深入研究打下坚实的基础。

Insulin Resistance(IR) is one of the main pathogeneses of Type 2 diabetes(T2DM). The key to treating T2DM is to improve the body’s IR state. Traditional Chinese medicine has unique advantages in alleviating IR. In recent years,more and more researchers have begun to pay attention to the role of Chinese medicine in alleviating IR in T2DM, and the research on its molecular mechanism has become more and more in-depth. In view of the intricate relationship between IR and chronic low-grade inflammation, based on two major types of pathways, classical insulin conduction and inflammatory signaling, this article summarized the effectiveness of traditional Chinese medicine in alleviating IR in the past ten years from three aspects: active ingredients, extracts, and Chinese herbal compound. It aims to provide reference for the research and treatment of T2DM and IR with traditional Chinese medicine, and to lay a solid foundation for further in-depth research.