摘要
母体不良内分泌环境严重影响子代各系统生长发育。本文综述了近年来宫内高雄激素环境对子代健康影响的人群队列、动物实验以及相关机制研究,为未来高雄激素暴露与子代慢性疾病发生的研究方向、机制探寻、早期干预提供新视角。
Maternal adverse endocrine environment severely affects the growth and development of offspring.This article reviews relevant cohort studies and animal experiments on the influence of intrauterine hyper androgen on offspring health and the mechanisms,aiming to provide a new perspective for further research,mechanism exploration,and early interventions in this field.
作者
霍雨
王文佶
桂永浩
Huo Yu;Wang Wenji;Gui Yonghao(National Children's Medical Center,Children′s Hospital of Fudan University(National Health Commission Key Laboratory of Neonatal Diseases,Fudan University),Shanghai 201102,China)
出处
《中华围产医学杂志》
CAS
CSCD
北大核心
2022年第10期765-770,共6页
Chinese Journal of Perinatal Medicine
基金
儿童早期健康与维护创新平台建设项目(XM06221237)。
关键词
雄激素类
产前暴露迟发效应
婴儿
出生时低体重
心肌病
肥厚性
胰岛素抵抗
脂代谢障碍
葡萄糖代谢障碍
Androgens
Prenatal exposure delayed effects
Infant,low birth weight
Cardiomyopathy,hypertrophic
Insulin resistance
Lipid metabolism disorders
Glucose metabolism disorders