糖尿病共病抑郁患者尿液挥发性有机化合物分析

Analysis of volatile organic compounds in urine of diabetic patients comorbid with depression

目的比较糖尿病患者与糖尿病共病抑郁患者尿液挥发性有机化合物(VOCs)的差别。方法纳入2019年11月至2020年11月在上海交通大学附属第六人民医院南院住院治疗,并符合防治指南诊断标准的2型糖尿病患者,利用PHQ9量表进行抑郁症筛查,根据评分将纳入研究的患者分为两组,分别为单纯糖尿病组和糖尿病共病抑郁组。采集患者晨尿,利用微型气体测试装置检测尿液中的挥发性有机化合物。结果纳入研究患者合计161例,其中单纯糖尿病组141例,糖尿病共病抑郁组20例。微型气体测试装置灵敏度为80%,特异性为98%,准确性为92.8%。两组患者的尿液挥发性有机化合物存在差异。结论糖尿病共病抑郁患者与糖尿病患者相比,尿液中的挥发性有机化合物组成可能发生改变,可为临床早期诊断抑郁症提供实验参考。

Objective To compare the difference of volatile organic compounds(VOCs)in the urine of diabetic patients comorbid with or without depression.Methods Patients with type 2 diabetes who met the diagnostic criteria of prevention and treatment guidelines and were treated in inpatient department of Sixth People’s Hospital South Campus,Shanghai Jiaotong University,from November 2019 to November 2020 were included in the study.Depression screening was performed using PHQ9 scale.According to the scores,the patients were divided into two groups:diabetic patient group and diabetic patient comorbidity depression group.The morning urine was collected and VOCs in urine were detected using a miniature gas tester.Results A total of 161 patients with diabetes mellitus,including 141 patients in the diabetic group and 20 patients in the diabetic comorbidity depression group.The results indicated that the sensitivity,specificity and accuracy of the method are 80%,98%and 92.8%respectively.There were differences in urine volatile organic compounds between the two groups.Conclusions Compared with diabetic patients,the composition of volatile organic compounds in urine may change after diabetic comorbidity depression,which can provide experimental reference for early clinical diagnosis of depression.