经皮椎体成形术联合适形放射治疗对椎体转移瘤患者的治疗效果

Therapeutic effect of percutaneous vertebroplasty combined with conformal radiation therapy in patients with vertebral metastases

目的探讨经皮椎体成形术(PVP)联合适形放射治疗对椎体转移瘤患者的治疗效果。方法根据治疗方法的不同将60例椎体转移瘤患者分为对照组和观察组,每组30例,对照组患者接受单纯适形放射治疗,观察组患者接受PVP联合适形放射治疗。比较两组患者的临床疗效、疼痛程度[视觉模拟评分法(VAS)]、体力状态[美国东部肿瘤协作组(ECOG)体力状态评分]、不良反应发生情况及生存情况。结果观察组患者的疾病控制率为93.33%,高于对照组患者的73.33%,差异有统计学意义(P﹤0.05)。治疗1天、7天、1个月和3个月后,两组患者的VAS评分均低于本组治疗前,且观察组患者的VAS评分均低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,观察组患者的ECOG体力状态评分优于对照组(P﹤0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P﹥0.05)。观察组患者的1年无病生存率和总生存率均高于对照组,差异均有统计学意义(P﹤0.05)。结论PVP联合适形放射治疗对椎体转移瘤患者具有较好的临床疗效和安全性,还能够缓解患者疼痛,促进患者体力恢复,提高其生存率,治疗效果较为显著。

Objective To investigate the therapeutic effect of percutaneous vertebroplasty(PVP)combined with com-formal radiation therapy in patients with vertebral metastases.Method A total of 60 patients with vertebral metastases were divided into control group and observation group according to different treatment methods,with 30 cases in each group.The patients in the control group received conformal radiation therapy alone,while the patients in the observation group received PVP combined with conformal radiation therapy.The clinical efficacy,pain level[visual analogue scale(VAS)],performance status[Eastern Cooperative Oncology Group(ECOG)performance status score],adverse events,and survival were compared between the two groups.Result The disease control rate in the observation group was 93.33%,which was higher than 73.33%in the control group,and the difference was statistically significant(P<0.05).Af-ter 1 day,7 days,1 month,and 3 months of the treatment,the VAS scores of the two groups were lower than those before the treatment,and the VAS scores of the observation group were lower than those of the control group,and the differenc-es were statistically significant(P<0.05).After the treatment,the ECOG performance status score of the observation group was better than that of the control group(P<0.05).There was no significant difference in the total incidence of ad-verse events between the two groups(P>0.05).The 1-year disease-free survival rate and overall survival rate of the ob-servation group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion PVP combined with conformal radiation therapy has good clinical efficacy and safety in treating vertebral metastases.This therapy could also relieve pain,promote physical recovery,and improve survival rate and the therapeutic effect is relatively effective.