纳米技术抗耐药菌的研究进展

Research Progress of Nanotechnology to Enhance Antibacterial Efficacy of Antibacterial Drugs

细菌耐药性问题已成为全世界的共同挑战,其导致抗菌药物的作用下降,细菌性疾病发病率及死亡率不断攀升。疾病治疗难度加大、治疗费用增加以及动物生产力的持续降低,给畜牧养殖业造成严重经济损失。因此,寻找新方案以对抗耐药细菌尤为重要。纳米技术于近代兴起,被广泛运用于生物医学等多个领域,在对抗耐药细菌方面具有显著优势。纳米技术可通过破坏细菌细胞膜、抑制外排泵、产生活性氧(ROS)、抑制和降解生物被膜等多种机制降低细菌抗性。本文将从纳米技术的应用历程、对抗耐药菌的策略以及对抗耐药菌机制等三个方面进行简要概述,以期为兽药研究者提供一定借鉴。

The problem of bacterial resistance become a common challenge in the world,which leads to a decline in the effect of antimicrobial drugs and a rise in the incidence and mortality of bacterial diseases.The increase of treatment difficulty,expensive therapeutic cost and continuous decrease of animal productivity have caused serious economic losses to animal husbandry.Therefore,it is particularly necessary to find new schemes to fight resistant bacteria.Nanotechnology rose in modern times and has been widely used in many fields,such as biomedicine.It has a significant effect in fighting resistant bacteria,which can reduce bacterial resistance through various mechanisms such as destroy bacterial cell membrane,inhibiting efflux pump,produce reactive oxygen species(ROS) and degrading biofilm.This article will briefly summarize nanotechnology,about its development history,strategies to fight resistant bacteria and mechanisms to fight bacterial resistance,in order to provide some reference for veterinary drug researchers.