肿瘤患者应用抗肿瘤药物不良反应的临床分析

Clinical Analysis of Adverse Reactions of Antitumor Drugs in Tumor Patients

目的:分析肿瘤患者应用抗肿瘤药物的不良反应。方法:选取2020年4月-2021年3月在重庆三峡医药高等专科学校附属人民医院住院治疗且发生不良反应的74例肿瘤患者作为研究对象。回顾性分析患者应用抗肿瘤药物类型、不良反应累及器官、用药途径和用药方式。结果:74例患者中,男35例(47.30%),女39例(52.70%);年龄>60岁的患者最多,占40.54%;其次是51~60岁患者,占20.27%。抗肿瘤药物类型以细胞毒性药物为主,占87.84%;其次是靶向治疗药物,占6.76%。不良反应累及器官以血液系统为主,占51.35%;其次是消化系统,占33.78%。用药途径以静脉注射为主,占90.54%;用药方式以联合用药为主,占70.27%。结论:肿瘤患者使用抗肿瘤药物时,不良反应发生率较高,提示医护人员应制定针对性的用药管理措施,提高用药合理性和安全性。

Objective:To analyze the adverse reactions of antitumor drugs in tumor patients.Methods:From April 2020 to March 2021,74 tumor patients hospitalized in Chongqing Three Gorges Medicine College Affiliated People's Hospital and developing adverse reactions were selected as the study subjects.The types of antitumor drugs,the organs involved in adverse reactions,the routes and mode of administration were retrospectively analyzed.Results:Among 74 patients,35 cases were male,accounting for 47.30%,39 cases were women,accounting for 52.70%.The patients aged over 60 years were dominant,accounting for 40.54%,followed by those aged 51~60 years,accounting for 20.27%.The types of antitumor drugs were mainly cytotoxic drugs,accounting for 87.84%;followed by targeted therapeutic drugs,accounting for 6.76%.The main organs involved in adverse reactions were the blood system,accounting for 51.35%;followed by the digestive system,accounting for 33.78%.The main route of administration was intravenous injection,accounting for 90.54%.The main mode of administration was the combination,accounting for 70.27%.Conclusion:When tumor patients use antitumor drugs,the incidence of adverse reactions is high,suggesting that medical staff should develop targeted drug management measures,improve the rationality and safety of medication.