去甲肾上腺素注射液治疗重症监护室脓毒性休克的效果观察

Effect Observation of Norepinephrine Injection in Treatment of Septic Shock in ICU

目的:探讨去甲肾上腺素注射液治疗重症监护室(ICU)脓毒性休克患者的效果。方法:选取2020年1月-2021年12月东莞市人民医院收治的198例ICU脓毒性休克患者为研究对象,根据治疗方法的不同将患者分为对照组和观察组,各99例。观察组应用去甲肾上腺素治疗,对照组应用多巴胺治疗。比较两组血乳酸清除率、血流动力学指标及抢救成功率。结果:观察组治疗后6 h、12 h、24 h、48 h的血乳酸清除率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组平均动脉压(MAP)、心率(HR)及心脏指数(CI)水平比较,差异无统计学意义(P>0.05);治疗后6 h、12 h、24 h、48 h,两组MAP、CI水平比较,差异无统计学意义(P>0.05);治疗后6 h、12 h、24 h、48 h,观察组HR水平低于对照组,差异有统计学意义(P<0.05)。观察组抢救成功率(97.98%)高于对照组(90.91%),差异有统计学意义(P<0.05)。结论:去甲肾上腺素注射液治疗ICU脓毒性休克的效果显著,可提高患者血乳酸清除率,在降低HR的同时,不会对患者的MAP、CI造成影响,有效提高患者抢救成功率,值得推广。

Objective:To investigate the effect of norepinephrine injection in the treatment of patients with septic shock in intensive care unit(ICU).Methods:A total of 198 ICU patients with septic shock admitted to Dongguan People's Hospital from January 2020 to December 2021 were selected as study subjects,and the patients were divided into control group and observation group according to different treatment methods,with 99 cases in each group.The observation group was treated with norepinephrine and the control group was treated with dopamine.Blood lactate clearance rate,hemodynamic indexes and rescue success rate between two groups were compared.Results:At 6 h,12 h,24 h and 48 h after treatment,the blood lactate clearance rate in the observation group was higher than that in the control group,with a statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference between the mean arterial pressure(MAP),heart rate(HR)and cardiac index(CI)levels between the two groups(P>0.05).At 6 h,12 h,24 h and 48 h after treatment,the MAP and CI levels of the two groups showed no significant difference(P>0.05).At 6 h,12 h,24 h,and 48 h after treatment,the HR level in the observation group was lower than that in the control group,with a statistically significant difference(P<0.05).The rescue success rate in the observation group(97.98%),which was higher than that in the control group 90.91%,and the difference was statistically significant(P<0.05).Conclusion:The effect of norepinephrine injection in the treatment of septic shock in ICU is significant.It can increase blood lactate clearance rate and reduce the HR of patients,without any affection on MAP and CI of patients,and can effectively increase the success rate of rescue.So it deserves the promotion.