药师主导管理模式对非瓣膜性房颤住院患者华法林标准化抗凝治疗效果的影响

Study on standardized warfarin anticoagulation in hospitalized patients with nonvalvular atrial fibrillation under the mode of pharmacist-led management

目的分析药师主导管理模式对非瓣膜性房颤住院患者华法林标准化抗凝治疗效果的影响。方法选取某院2020年1月~2021年6月采用华法林标准化抗凝治疗的非瓣膜性房颤住院患者105例,随机分为对照组(n=49)和观察组(n=56)。两组均采用华法林标准化抗凝治疗,对照组由临床医师主导抗凝管理,观察组由临床药师主导抗凝管理并提供全面健康教育。比较两组患者在治疗后的服药依从性、INR达标率及抗凝知识知晓程度。结果治疗后,观察组的服药依从性和INR达标率均高于对照组(P<0.05);对于抗凝知识的掌握程度,观察组优于对照组(P<0.05)。结论药师主导管理模式对非瓣膜性房颤住院患者华法林标准化抗凝治疗效果有积极促进作用,提高了患者的服药依从性和INR达标率,增加了治疗的有效性和安全性。

Objective To analyze the effect of pharmacist-led management on standardized warfarin anticoagulation in hospitalized patients with nonvalvular atrial fibrillation.Methods From January 2020 to June 2021,the standardization of warfarin anticoagulation therapy for 105 inpatients with non-valvular atrial fibrillationin in our hospital were selected,whom were randomly divided into control group(n=49)and observation group(n=56).Both groups received standardized warfarin anticoagulation therapy.The anticoagulant management was led by clinicians in the control group,while the observation group was led by clinical pharmacists and provided comprehensive health education.After treatment,medication compliance,INR compliance rate and knowledge of anticoagulation were compared between the two groups.Results After treatment,the medication compliance and INR compliance rate of the observation group were higher than those of the control group(P<0.05),and knowledge of anticoagulation of the observation group was better than that of the control group(P<0.05).Conclusion The mode of pharmacist-led management can positively promote the effect of standardized warfarin anticoagulation in hospitalized patients with nonvalvular atrial fibrillation,improve the treatment compliance and INR compliance rate,and increase the effectiveness and safety of medication.