老年住院患者衰弱综合征与认知功能障碍和抑郁的相关性分析

Correlation analysis of frailty syndrome with cognitive dysfunction and depression among elderly inpatients

目的探讨老年住院患者衰弱综合征与认知功能障碍及抑郁的相关性。方法选取2019年2月—2020年2月在杭州市第七人民医院治疗的老年患者178例,根据Fried衰弱评估量表将患者分为非衰弱组(42例)、衰弱前期组(64例)和衰弱组(72例)。比较3组患者的一般临床资料,分析衰弱与认知功能障碍和抑郁的相关性,并探讨影响衰弱的危险因素。结果3组患者性别、年龄、慢性疾病数量、IL-6、CRP、ALB等方面比较差异有统计学意义(均P<0.05);衰弱组认知功能障碍和抑郁发生率[43(59.72%)、31(43.06%)]明显高于非衰弱组[3(7.14%)、1(2.38%)]和衰弱前期组[21(32.81%)、15(23.43%)],均P<0.017,而衰弱前期组明显高于非衰弱组(均P<0.017);衰弱严重程度与认知功能和抑郁发生率呈正相关关系(r=0.138,P=0.017;r=0.163,P=0.004);Logistic回归分析显示,年龄、慢性疾病数量、认知功能障碍、抑郁是老年患者衰弱发生的独立影响因素。结论老年住院衰弱综合征患者的衰弱程度与认知功能障碍、抑郁呈正相关关系;高龄、认知功能障碍、抑郁、慢性疾病数量多是影响老年衰弱综合征的独立危险因素。

Objective To investigate the correlation between frailty syndrome and cognitive dysfunction and depression in elderly inpatients.Methods A total of 178 cases of hospitalised elderly inpatients were selected in Hangzhou Seventh People's Hospital from February 2019 to February 2020.Based on the Fried scale,the inpatients were divided into non-frailty group(42 cases),pre-frailty group(72 cases)and frailty group(64 cases).The general clinical data of the three groups were compared to analyse the correlation between frailty and cognitive dysfunction and depression as well as to explore the risk factors affecting frailty.Results There was statistical significance found in gender,age,number of chronic diseases,IL-6,CRP and ALB among the three groups(all P<0.05).The incidence of cognitive dysfunction and depression in the frailty group[43(59.72%),31(43.06%)]was significantly higher than that in the non-frailty group[3(7.14%),1(2.38%)]and the pre-frailty group[21(32.81%),15(23.43%)],all P<0.017,and the pre-frailty group was significantly higher than that in the non-frailty group(all P<0.017).Meanwhile,the severity of frailty were significantly positively correlated with cognitive function and the incidence of depression(r=0.138,P=0.017;r=0.163,P=0.004),respectively.Logistic regression analysis showed that age,number of chronic diseases,cognitive dysfunction and depression were independent risk factors for frailty in elderly inpatients.Conclusion The frailty degree of elderly inpatient frailty syndrome is positively correlated with cognitive dysfunction and depression.Therefore,old age,cognitive dysfunction,depression and several chronic diseases are independent risk factors for elderly frailty syndrome.