肠源性尿毒症毒素的研究进展

Research advances in the gut-derived uremic toxins

肠源性尿毒症毒素(gut-derived uremic toxins,GUTs)加速慢性肾脏病进展,导致终末期肾病(end-stage renal disease,ESRD)患者出现多种并发症、增加患者死亡率,但难以被透析直接清除。基于清除GUTs的治疗策略,包括膳食调节、菌群调节、口服吸附剂及血液净化方式的改进等,对于ESRD患者至关重要。本文将对GUTs及以其为靶点的治疗方面的研究进展做一综述。

Gut-derived uremic toxins(GUTs)accelerate the progression of chronic kidney disease,leading to various complications and increased mortality in patients with end-stage renal disease(ESRD).GUTs are difficult to be removed directly by dialysis.Therapeutic strategies to clear GUTs include dietary modifications,flora modifications,oral adsorbents and improvement of hemodialysis modalities.Clearance of GUTs is critical for ESRD patients.This article reviews the research advances in GUTs and the related therapies.