6-氢嘌呤衍生物的合成研究

Synthesis of 6-Hydropurine Derivatives

6-氢嘌呤衍生物表现出广泛的生物活性,是一类极具医药研究价值的小分子类化合物。本文采用6-氯嘌呤衍生物为原料,采用Pd/C为催化剂,甲酸铵为还原剂,成功实现6位脱氯还原制备6-氢嘌呤衍生物,并利用该方法成功制备15个6-氢嘌呤衍生物,表明该合成路线有着良好的官能团兼容性,产物结构经^(1)H NMR、^(13)C NMR及HRMS确证。本路线的成功探索,为新型嘌呤衍生物的合成提供了技术参考。

6-hydropurine derivatives with good biological activity have potential value in medical research.In this paper,6-hydropurine derivatives were synthesized by using 6-chloropurine derivatives as raw material via reduction reaction at 6-position.Fifteen 6-hydropurine derivatives have been prepared by this method,which shows that this route has good functional group compatibility.The structures of the target products were confirmed by ^(1)H NMR,^(13)C NMR and HRMS.The successful exploration of this route provides a technical reference for the synthesis of novel purine derivatives.