盐酸氨基葡萄糖联合塞来昔布治疗膝骨关节炎的效果及对炎症因子的影响

Effect of Glucosamine Hydrochloride combined with Celecoxib in patients with knee osteoarthritis and its effect on inflammatory factors

目的探讨盐酸氨基葡萄糖联合塞来昔布治疗膝骨关节炎的效果及对炎症因子的影响。方法选取2020年6月至2021年6月南京医科大学附属江宁医院收治的62例膝骨关节炎患者为研究对象,采用随机数字表法分为常规组、观察组,每组31例。常规组行塞来昔布治疗,观察组在常规组的基础上另给予盐酸氨基葡萄糖治疗,两组均持续治疗8周后观察效果。比较两组患者ISOA评分、C反应蛋白(CRP)、临床疗效,记录治疗期间不良反应发生情况。结果两组患者治疗前ISOA评分、CRP比较,差异无统计学意义(P>0.05);两组患者治疗后的ISOA评分、CRP均低于治疗前,差异有统计学意义(P<0.05);观察组治疗后的ISOA评分、CRP低于常规组,差异有统计学意义(P<0.05)。观察组总有效率高于常规组,差异有统计学意义(P<0.05)。观察组不良反应总发生率低于常规组,差异有统计学意义(P<0.05)。结论盐酸氨基葡萄糖联合塞来昔布治疗膝骨关节炎可降低膝骨关节炎的严重性评分,提高临床疗效,降低不良反应发生率。

Objective To investigate the effect of Glucosamine Hydrochloride combined with Celecoxib in the treatment of knee osteoarthritis and its effect on inflammatory factors.Methods A total of 62 patients with knee osteoarthritis treated in Jiangning Hospital Affiliated to Nanjing Medical University from June 2020 to June 2021 were selected as the research objects.They were divided into routine group and observation group by random number table method,with 31 cases in each group.The conventional group was treated with Celecoxib,and the observation group was treated with Glucosamine Hydrochloride on the basis of the conventional group.The effects of the two groups were observed after 8 weeks of continuous treatment.The severity Index of osteoarthritis(ISOA)score,C-reactive protein(CRP)and clinical efficacy of the two groups were compared,and the adverse reactions during treatment were recorded.Results There were no significant differences in the ISOA score and CRP between the two groups before treatment(P>0.05).The ISOA score and CRP of the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The ISOA score and CRP of the observation group after treatment were lower than those of the conventional group,and the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the routine group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the routine group,and the difference was statistically significant(P<0.05).Conclusion Glucosamine Hydrochloride combined with Celecoxib in the treatment of knee osteoarthritis can reduce the severity score of knee osteoarthritis,improve the clinical efficacy and reduce the incidence of adverse reactions.