低分子肝素钠治疗复发性流产的疗效观察

Curative effect observation of low molecular weight Heparin Sodium on recurrent abortion

目的探讨低分子肝素钠治疗复发性流产的效果。方法选取2019年12月至2021年4月新余市妇幼保健院收治的60例复发性流产确诊患者作为研究对象,按照随机数字表法分为对照组和观察组,每组30例。对照组采用地屈孕酮联合间苯三酚治疗,观察组在对照组的基础上,对患者进行低分子肝素钠皮下注射治疗。比较两组患者的妊娠结局、性激素水平、妊娠并发症。结果观察组活产率、异位妊娠率高于对照组,流产率、胎死宫内率低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者人绒毛膜促性腺激素(HCG)、孕酮(P)、雌二醇(E_(2))水平比较,差异无统计学意义(P>0.05);治疗后,两组患者HCG、P、E_(2)水平均高于本组干预前,且观察组HCG、P、E_(2)水平均高于对照组,差异有统计学意义(P<0.05)。观察组妊娠并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论低分子肝素钠治疗复发性流产效果较好,可以提高患者的活产率,改善HCG、P、E_(2)水平,降低妊娠并发症发生率。

Objective To investigate the efficacy of low molecular weight Heparin Sodium in the treatment of recurrent abortion.Methods A total of 60 patients with recurrent abortion admitted to Xinyu Maternal and Child Health Hospital from December 2019 to April 2021 were selected as the research objects.According to the random number table method,they were divided into control group and observation group,with 30 cases in each group.Control group was treated with Didroxyprogesterone combined with Phloroglucinol.Observation group was treated with subcutaneous injection of low molecular weight Heparin Sodium on the basis of the control group.The pregnancy outcome,sex hormone level and pregnancy complications were compared between the two groups.Results The live birth rate and the rate of ectopic gestation of the observation group were higher than those of the control group,the abortion rate,the rate of fetal death in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in the levels of human chorionic gonadotropin(HCG),progesterone(P)and estradiol(E_(2))between the two groups before intervention(P>0.05).After treatment,the levels of HCG,P and E_(2) in the two groups were higher than those before intervention,and the levels of HCG,P and E_(2) in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The total incidence of pregnancy complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Low molecular weight Heparin Sodium is effective in the treatment of recurrent abortion.It can improve the live birth rate,improve the levels of HCG,P and E_(2),and reduce the incidence of pregnancy complications.