血液灌流对维持性透析患者认知功能的影响

Effect of hemoperfusion on the cognitive functions of patients on maintenance hemodialysis

目的探讨血液灌流对维持性血液透析患者认知功能的影响。方法选取2019年1月至2021年11月于寿光和信医院透析室维持性血液透析的84例患者作为研究对象,采用随机数字表法将其分为观察组与对照组,每组各42例。两组患者均进行常规性维持血液透析,观察组患者每周加1次血液灌流。比较两组患者治疗前后的认知功能评分。结果治疗前,观察组患者的时间与空间定向力评分为(2.09±0.42)分,记忆力评分为(2.02±0.40)分,注意与计算力评分为(2.44±0.49)分,回忆力评分为(2.29±0.46)分,语言能力评分为(2.24±0.45)分,视觉空间能力评分为(2.32±0.47)分,简易精神状况评估表(MMSE)总评分为(18.07±3.62)分,与对照组的(2.16±0.43)、(2.14±0.43)、(2.36±0.47)、(2.25±0.45)、(2.17±0.43)、(2.21±0.44)、(17.94±3.60)分比较,差异均无统计学意义(P>0.05)。治疗后,观察组患者的时间与空间定向力评分为(3.40±0.68)分,记忆力评分为(3.35±0.67)分,注意与计算力评分为(2.00±0.40)分,回忆力评分为(3.46±0.69)分,语言能力评分为(3.47±0.69)分,视觉空间能力评分为(1.91±0.38)分,MMSE总评分为(25.82±5.14)分,均高于对照组[(2.48±0.49)、(2.38±0.47)、(2.04±0.41)、(2.52±0.50)、(2.54±0.51)、(2.01±0.40)、(20.63±4.11)分],差异有统计学意义(P<0.05)。结论血液灌流能在一定程度上改善维持性血液透析患者的认知功能。

Objective To investigate the effect of hemoperfusion on the cognitive functions of patients on maintenance hemodialysis.Methods A total of 84 patients who maintained hemodialysis in Dialysis Room of Shouguang Hesin Hospital from January 2019 to November 2021 were selected as the research objects.They were divided into observation group and control group by random number table method,with 42 cases in each group.Routine maintenance hemodialysis was performed in both groups,and hemoperfusion was added once a week in the observation group.The cognitive function scores before and after treatment were compared between the two groups.Results Before treatment,the scores of temporal and spatial orientation,memory,attention and computation,recall,language ability,visuospatial ability and the total score of mini-mental state examination(MMSE)of the observation group were(2.09±0.42),(2.02±0.40),(2.44±0.49),(2.29±0.46),(2.24±0.45),(2.32±0.47)and(18.07±3.62)points,respectively,compared with the control group of(2.16±0.43),(2.14±0.43),(2.36±0.47),(2.25±0.45),(2.17±0.43),(2.21±0.44),(17.94±3.60)points,there were no significant differences(P>0.05).After treatment,the scores of temporal and spatial orientation,memory,attention and computation,recall,language ability,visuospatial ability and the total score of MMSE of the observation group were(3.40±0.68),(3.35±0.67),(2.00±0.40),(3.46±0.69),(3.47±0.69),(1.91±0.38)and(25.82±5.14)points respectively,which were higher than those of the control group([2.48±0.49],[2.38±0.47],[2.04±0.41],[2.52±0.50],[2.54±0.51],[2.01±0.40],[20.63±4.11]points),the differences were statistically significant(P<0.05).Conclusion Blood perfusion can improve and maintain the cognitive function of hemodialysis patients to a certain extent.