热休克蛋白在不明原因复发性流产中的研究进展

Advances in the roles of heat shock proteins in unexplained recurrent spontaneous abortion

临床中常见不明原因复发性流产(URSA)。母胎界面免疫、子宫内膜蜕膜化、细胞自噬与凋亡、生殖细胞发育及男性精子因素、母体雌孕激素水平、同型半胱氨酸代谢等多种因素异常均与URSA有关。该文针对热休克蛋白在上述相关因素中的研究进行综述,以期为URSA病理机制和临床干预技术的进一步研究提供参考。

Unexplained recurrent spontaneous abortion(URSA)is commonly seen in clinical practice.Multiple factors such as immune responses at the maternal-fetal interface,endometrial decidualization,autophagy and apoptosis,germ cell development,sperm abnormalities,maternal estrogen and progesterone levels and homocysteine metabolism are related to the occurrence of URSA.This review summarizes the studies on the roles of heat shock proteins in the aforementioned conditions,in order to provide references for the further investigation of the pathogenesis of and clinical intervention strategies for URSA.