醒脑解毒汤联合常规治疗细菌性脑膜炎疗效观察及对炎症因子的影响

Clinical Observation of Xingnao Jiedu Tang Combined with Routine Treatment for Bacterial Meningitis and Its Effect on Inflammatory Factors

目的:观察醒脑解毒汤联合常规治疗细菌性脑膜炎的临床疗效及其对炎症因子的影响。方法:选取96例细菌性脑膜炎患者,根据病例尾号按照奇偶数字法分为观察组和对照组各48例。对照组给予注射用头孢曲松钠、地塞米松等常规西药治疗,观察组在对照组的基础上加用醒脑解毒汤治疗。观察比较2组临床疗效、炎症因子水平变化及并发症发生率。结果:观察组总有效率为89.58%,对照组为72.92%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组C-反应蛋白(CRP)、血清肿瘤坏死因子-α (TNF-α)、脑脊液中白细胞介素-6(IL-6)及白细胞介素-8(IL-8)水平比较,差异无统计学意义(P>0.05);治疗后,2组CRP、TNF-α、IL-6、IL-8水平均较治疗前降低(P<0.05),且观察组各项指标均低于对照组(P<0.05)。观察组并发症发生率为2.08%,对照组为4.17%,2组比较,差异无统计学意义(P>0.05)。结论:醒脑解毒汤联合常规治疗细菌性脑膜炎疗效显著,可有效抑制炎症反应,且并发症相对较少,有利于病情康复。

Objective: To observe the clinical effect of Xingnao Jiedu tang combined with routine treatment for bacterial meningitis and its effect on inflammatory factors. Methods:A total of 96 cases of patients with bacterial meningitis were selected and divided into the observation group and the control group by odd-even number grouping method according to the tail number of cases, 48 cases in each group. The control group was given routine western medicine treatment including ceftriaxone sodium for injection and dexamethasone,and the observation group was additionally treated with Xingnao Jiedu tang based on the treatment of the control group. Clinical effects,changes in the levels of inflammatory factors and incidences of complications in the two groups were observed and compared. Results: The total effective rate was 89.58% in the observation group and 72.92% in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of C-reactive protein(CRP), serum tumor necrosis factor-α(TNF-α) as well as interleukin-6(IL-6) and interleukin-8(IL-8) in cerebrospinal fluid between the two groups(P>0.05). After treatment,the levels of CRP, TNF-α, IL-6 and IL-8 in the two groups were decreased when compared with those before treatment(P<0.05),and all indexes in the observation group were lower than those in the control group(P<0.05). The incidence of complications was 2.08% in the observation group and 4.17% in the control group, there being no significant difference between the two groups(P>0.05). Conclusion: The therapy of Xingnao Jiedu tang combined with routine treatment has a significant curative effect in treating bacterial meningitis,which can effectively inhibit inflammatory reactions with fewer complications,and is conducive to rehabilitation of the disease.