小儿柴桂退热颗粒联合奥司他韦治疗小儿甲型流感临床研究

Clinical Study on Xiao’er Chaigui Tuire Granules Combined with Oseltamivir for Influenza A in Children

目的:观察小儿柴桂退热颗粒联合奥司他韦治疗小儿甲型流感的临床疗效。方法:选取92例甲型流感患儿,依据随机数字表法分为对照组与观察组,每组46例。对照组使用奥司他韦治疗,观察组在对照组基础上给予小儿柴桂退热颗粒治疗,2组均连续治疗7 d。比较2组临床疗效、临床症状持续时间(发热、咽喉肿痛、卡他症状持续时间)、不良反应发生率及治疗前后血清炎症因子[超敏C-反应蛋白(hs-CRP)、白细胞介素-4 (IL-4)、干扰素-γ (IFN-γ)]水平。结果:观察组显效率60.87%,高于对照组43.48%(P<0.05)。观察组发热、咽喉肿痛、卡他症状持续时间均短于对照组(P<0.05)。治疗后,2组血清hs-CRP、IL-4、IFN-γ水平均较治疗前降低,观察组血清hs-CRP、IL-4、IFN-γ水平均低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率21.74%,与对照组13.04%比较,差异无统计学意义(P>0.05)。结论:小儿柴桂退热颗粒联合奥司他韦治疗小儿甲型流感,可在短时间内改善临床症状,抑制炎症反应,具有良好的安全性。

Objective: To observe the clinical effect of Xiao’er Chaigui Tuire granules combined with oseltamivir for influenza A in children. Methods: A total of 92 cases of children with influenza A were selected and divided into the control group and the observation group,with 46 cases in each group. The control group was treated with oseltamivir,and the observation group was additionally treated with Xiao’er Chaigui Tuire granules based on the treatment of the control group. Both groups were treated for seven days. Clinical effects, the duration of clinical symptoms including fever, pharyngeal pain and catarrhal symptoms, and the incidence of adverse reactions were compared between the two groups. Levels of inflammatory factors including high-sensitivity C-reactive protein(hs-CRP), interleukin-4(IL-4) and interferon-γ(IFN-γ) in serum before and after treatment were compared between the two groups. Results:The effective rate was 60.87% in the observation group,better than that of 43.48% in the control group(P<0.05). The duration of fever,pharyngeal pain and catarrhal symptoms in the observation group were shorter than those in the control group(P<0.05). After treatment,levels of hs-CRP,IL-4 and IFN-γ in serum in the two groups were decreased when compared with those before treatment,and the three levels above in the observation group were lower than those in the control group,differences being significant(P<0.05).The incidence of adverse reactions was 21.74% in the observation group and 13.04% in the control group,there being no significance in the difference(P>0.05). Conclusion:Xiao’er Chaigui Tuire granules combined with oseltamivir for influenza A in children can improve clinical symptoms in a short time and inhibit inflammatory responses,with good safety.