基于出生队列的孕早期夜间睡眠时长联合打鼾暴露与SGA和LGA的关联研究

Association between nocturnal sleep duration combined with snoring exposure and SGA,LGA in the first trimester of pregnancy based on birth cohort

目的探讨孕产妇孕早期夜间睡眠时长联合打鼾与小于胎龄儿(SGA)、大于胎龄儿(LGA)的病因关联。方法采用多因素Logistic回归模型考察夜间睡眠时长、打鼾及其联合作用与SGA和LGA的关联效应。结果与孕早期夜间睡眠时长7~9 h相比,睡眠时长<7 h与男婴SGA呈正相关(OR=4.22,95%CI:1.69~10.52);按孕早期是否打鼾分组后,打鼾孕妇孕早期夜间睡眠时长<7 h与SGA呈正相关(OR=5.68,95%CI:1.02~31.51),不打鼾孕妇孕早期夜间睡眠时长<7 h与LGA呈正相关(OR=2.10,95%CI:1.16~3.81)。结论孕早期夜间睡眠时长<7 h是SGA和LGA的危险因素,且打鼾可能增强孕早期睡眠时长<7 h与SGA的关联。孕妇应保持足够的夜间睡眠时长降低新生儿体质量异常的风险。

Objective To investigate the correlation between nocturnal sleep duration combined with snoring in the first trimester of pregnancyand small for gestational age(SGA),large for gestational age(LGA).Methods Multivariate Logistic regression model was used to analyze the association between nocturnal sleep duration,snoring,their combined effects and SGA,LGA.Results Compared to nocturnal sleep duration 7 to 9 h in the first trimester of pregnancy,sleep duration<7 h was positively correlated with SGA in male newborn(OR=4.22,95%CI:1.69-10.52);After stratified by snoring,the sleep duration of snoring women<7 h was positively correlated with SGA(OR=5.68,95%CI:1.02-31.51),and the sleep duration of non-snoring women<7 h was positively correlated with LGA(OR=2.10,95%CI:1.16-3.81).Conclusion Sleep duration<7 h in the first trimester of pregnancy is a risk factor for SGA and LGA,and snoring may enhance the association between sleep duration<7 h in the first trimester of pregnancy and SGA.Pregnant women should keep adequate nocturnal sleep duration to reduce the risk of abnormal neonatal weight.