细胞疗法治疗大便失禁的现状及展望

Current status and prospect of cell therapy for fecal incontinence

大便失禁是肛肠外科常见疾病,可导致患者生活质量下降,并引起一系列社会心理问题,其发病率随着年龄增加明显上升。肛门括约肌复合体损伤是大便失禁的最常见原因。目前的治疗方式包括保守治疗和手术治疗,但治疗效果仍不理想,尤其是长期治疗效果较差。最近,许多临床前和临床研究对大便失禁的干细胞疗法进行了探索,作为一种新的治疗方式,干细胞疗法有望彻底治愈大便失禁。本文就干细胞疗法治疗大便失禁的动物模型、损伤和修复机制、疗效等方面进行综述。

Fecal incontinence is a common anorectal surgical condition that can lead to decreased quality of life and a range of psychosocial problems in patients,and its incidence increases significantly with age.Damage to the anal sphincter complex is the most common cause of fecal incontinence.Current treatment modalities include conservative and surgical treatment,but treatment outcomes remain suboptimal,especially in the long term.Recently,many preclinical and clinical studies have explored stem cell therapy for fecal incontinence as a new treatment modality that holds promise for a complete cure of fecal incontinence.This paper presents a review of animal models,mechanisms of injury and repair,and efficacy of stem cell therapy for fecal incontinence.