孟鲁司特钠片联合盐酸左西替利嗪片治疗慢性荨麻疹的临床效果

Clinical effect of montelukast sodium tablets combined with levocetirizine hydrochloride tablets on chronic urticaria

目的探讨孟鲁司特钠片联合盐酸左西替利嗪片治疗慢性荨麻疹的效果。方法选取2019年7月至2020年7月我院收治的120例慢性荨麻疹患者作为研究对象,将其随机分为对照组和试验组,各60例。对照组给予盐酸左西替利嗪片治疗,试验组给予孟鲁司特钠片联合盐酸左西替利嗪片治疗。比较两组的治疗效果。结果试验组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,试验组的每日发作次数少于对照组,差异具有统计学意义(P<0.05)。治疗后,试验组的白细胞介素-4(IL-4)、白细胞介素-18(IL-18)、白三烯(LT)、免疫球蛋白E(IgE)、可溶性血管细胞黏附分子-1(SVCAM-1)水平均低于对照组,差异具有统计学意义(P<0.05)。治疗后,试验组的皮肤瘙痒、风团大小和风团数量评分低于对照组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。随访6个月,试验组的复发率低于对照组,差异具有统计学意义(P<0.05)。治疗后,试验组的皮肤病生活质量指数(DLQI)评分低于对照组,差异具有统计学意义(P<0.05)。治疗后,试验组的25-羟基维生素D[25(OH)D]水平高于对照组,差异具有统计学意义(P<0.05)。结论孟鲁司特钠片联合盐酸左西替利嗪片能够抑制炎症反应,缓解变态反应,提升慢性荨麻疹的治疗效果。

Objective To explore the effect of montelukast sodium tablets combined with levocetirizine hydrochloride tablets on chronic urticaria.Methods A total of 120 patients with chronic urticaria admitted in our hospital from July 2019to July 2020 were selected as the research objects and randomly divided into control group and experimental group,with 60cases in each group.The control group was treated with levocetirizine hydrochloride tablets,and the experimental group was treated with montelukast sodium tablets combined with levocetirizine hydrochloride tablets.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the number of daily attacks in the experimental group was less than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of interleukin-4(IL-4),interleukin-18(IL-18),leukotriene(LT),immunoglobulin E(IgE)and soluble vascular cell adhesion molecule-1(SVCAM-1)in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of skin itching,wheal size and number of wheals in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).After 6 months of follow-up,the recurrence rate in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the Dermatology Life Quality Index(DLQI)score in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the 25-hydroxyvitamin D[25(OH)D]level in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Montelukast sodium tablets combined with levocetirizine hydrochloride tablets can inhibit the inflammatory reaction,alleviate the allergic reaction,and improve the treatment effect of chronic urticaria.