复方甘草酸苷片联合类人胶原蛋白修复敷料治疗面部激素依赖性皮炎的临床效果及对患者皮肤屏障功能指标、生活质量的影响

Clinical effect of compound glycyrrhizin tablets combined with human-like collagen repair dressing in the treatment of facial hormone-dependent dermatitis and its influences on skin barrier function indexes and quality of life of patients

目的探讨复方甘草酸苷片联合类人胶原蛋白修复敷料治疗面部激素依赖性皮炎的临床效果及对患者皮肤屏障功能指标、生活质量的影响。方法选择2020年1月至2021年1月来我院就诊的98例面部激素依赖性皮炎患者作为研究对象,采用随机数字表法将其分为对照组(49例,复方甘草酸苷片治疗)和观察组(49例,复方甘草酸苷片+类人胶原蛋白修复敷料治疗)。比较两组的临床疗效、不良反应发生情况、皮肤屏障功能指标、心理状态、生活质量、面部症状及体征积分与满意度。结果观察组的治疗总有效率为95.92%,高于对照组的83.67%,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗前,两组的表皮油脂含量、表皮水分含量、经皮水分丢失量比较,差异无统计学意义(P>0.05);治疗后,两组的表皮油脂含量、表皮水分含量均增多,经皮水分丢失量均减少,且观察组优于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的焦虑自评量表(SAS)、抑郁自评量表(SDS)、皮肤病生活质量指数(DLQI)评分比较,差异无统计学意义(P>0.05);治疗后,两组的SAS、SDS、DLQI评分均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的面部症状及体征积分比较,差异无统计学意义(P>0.05);治疗后,两组的面部症状及体征积分均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。观察组的满意度为97.96%,高于对照组的81.63%,差异具有统计学意义(P<0.05)。结论复方甘草酸苷片联合类人胶原蛋白修复敷料治疗面部激素依赖性皮炎可以减轻患者的面部症状及体征,改善皮肤屏障功能及心理状态,提高治疗效果、生活质量及满意度,且安全性好,值得临床推广与应用。

Objective To explore the clinical effect of compound glycyrrhizin tablets combined with human-like collagen repair dressing in the treatment of facial hormone-dependent dermatitis and its influences on skin barrier function indexes and quality of life of patients.Methods A total of 98 patients with facial hormone-dependent dermatitis diagnosed in our hospital from January 2020 to January 2021 were selected as the research objects.The patients were divided into control group(49 cases,compound glycyrrhizin tablets treatment)and observation group(49 cases,compound glycyrrhizin tablets+human-like collagen repair dressing treatment)by random number table method.The clinical efficacy,occurrence of adverse reactions,skin barrier function indexes,psychological state,quality of life,facial symptoms and signs scores,and satisfaction were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.92%,which was higher than 83.67% in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Before treatment,there were no significant differences in epidermal oil content,epidermal water content and transepidermal water loss between the two groups(P>0.05);after treatment,the epidermal oil content and epidermal water content of the two groups increased,the transepidermal water loss decreased,and those in the observation group were better than the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the scores of Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS)and Dermatology Life Quality Index(DLQI)between the two groups(P>0.05);after treatment,the scores of SAS,SDS and DLQI in the two groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the scores of facial symptoms and signs between the two groups(P>0.05);after treatment,the scores of facial symptoms and signs in the two groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).The satisfaction of the observation group was 97.96%,which was higher than 81.63% of the control group,and the difference was statistically significant(P<0.05).Conclusion Compound glycyrrhizin tablets combined with human-like collagen repair dressing in the treatment of facial hormone-dependent dermatitis can reduce the facial symptoms and signs of patients,improve the skin barrier function and psychological state,improve the therapeutic effect,quality of life and satisfaction,and has good safety.It is worthy of clinical promotion and application.