摘要
代谢相关脂肪性肝病(MAFLD)是一组反映机体代谢功能障碍的高度异质性疾病,代谢相关脂肪性肝炎(MASH)是MAFLD病程中的重要阶段,可能发展为肝硬化、肝细胞癌,也是肝移植的常见病因。肝活检是MAFLD病理诊断的金标准,但存在有创、患者接受程度低等不足。因此,开发合适的无创诊断方法十分必要。近年,MAFLD无创诊断取得较大进展。本文主要从影像学和血清学生物标志物两方面入手,综述MAFLD无创诊断的相关进展。
Metabolic associated fatty liver disease(MAFLD)is a group of highly heterogeneous diseases reflecting metabolic dysfunction.Metabolic associated steatohepatitis(MASH)is a progressive stage in the course of MAFLD,which may develop into cirrhosis and hepatocellular carcinoma,and is also a common cause of liver transplantation.Liver biopsy is still considered as the gold standard for the diagnosis of MAFLD,but it is an invasive method and poorly accepted by patients.Therefore,it is essential to develop appropriate non-invasive diagnostic methods.In recent years,great progression has been made in the non-invasive diagnosis in MAFLD.This paper reviews the progression of non-invasive diagnosis of MAFLD and MASH from two aspects of imaging and serological biomarkers.
作者
李佳迅
江克清
钟伏弟
何松青
Li Jiaxun;Jiang Keqing;Zhong Fudi;He Songqing(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases,Guangxi Medical University,Nanning 530021,China;Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University),Ministry of Education,Nanning 530021,China)
出处
《中华实验外科杂志》
CAS
北大核心
2022年第9期1826-1830,共5页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金(82160120、91949122)
广西自然科学基金项目(2021GXNSFDA075002、2020GXNSFAA159050)
广西重点研发计划项目(2018AD03001)
111计划(D17011)
中央引导地方科技发展专项(ZY20198011)
广西科技基地和人才专项(桂科AA21220002)
广西医科大学第一附属医院肝脏损伤与修复重点实验室培育项目(YYZS2020001)
区域性高发肿瘤早期防治研究教育部重点实验室自主课题(GKE-ZZ202138、GKE-ZZ202114)
广西医科大学高水平创新团队及杏湖学者资助计划。
关键词
代谢相关脂肪性肝病
代谢相关脂肪性肝炎
无创诊断
Metabolic associated fatty Liver disease
Metabolic associated steatohepatitis
Non-invasive diagnosis
