生物表型和表型组标准化的现状与展望

Status and Prospects on the Standardization of Biological Phenotype and Phenome

随着高通量测序等现代分析技术的不断进步,探索生命体内在机理与外在表征的关系特别是生物表型组的研究愈发深入。而对基因、环境和表型关联研究的精准诉求,使得生物表型组的标准化变得至关重要。由于生物表型组涵盖范围广、种类多、表型特征差异大,无标准可依严重制约了科学研究以及行业发展。从标准化的角度,对生物表型相关概念、发展以及生物表型组标准化面临的问题进行分析与展望,以期对种类繁多、数据各异的生物表型组领域高质量发展提供计量技术及标准支持。

With the development of modern analytical techniques such as high-throughput sequencing,the research on exploring the relationship between mechanisms and external representations in life,especially the biological phenotyping,has become more and more in-depth.The precise demands of gene,environment and phenotype association research make the standardization research of biological phenome become crucial.Because phenome covers a wide range,many species,and the phenotypic characteristics differ greatly,there is no standard to follow,which seriously restricts scientific research and industrial development.From the perspective of standardization,the related concepts and development of biological phenotypes,as well as the problems faced by the standardization of biological phenome are analyzed and predicted,so as to provide metrological technology and standard support for the high-quality development in the field of biological phenome with various types and data.